Velocity variation assessment of red blood cell aggregation with spectral domain Doppler optical coherence tomography.
Velocity variation assessment of red blood cell aggregation with spectral domain Doppler optical coherence tomography.
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DOI：
10.1007/s10439-010-0066-7
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发表时间：
2010-10
影响因子：
3.8
通讯作者：
Chen, Zhongping
中科院分区：
文献类型：
--
作者：
Xu, Xiangqun;Yu, Lingfeng;Chen, Zhongping
关键词：
我们提出了光谱域多普勒光学相干层析成像(SD-D-OCT)来定性测量红细胞聚集性。提出了切变条件下血流多普勒方差成像的频谱方差/标准差(SD)作为一种新的聚集指标。在体外微通道流动实验中，用SD-D-OCT系统测量了不同凝集特性的猪血在葡聚糖500诱导和血浆纤维蛋白原存在下的聚集特性，光谱中心位于1310 nm。研究切变率、红细胞压积、聚集水平对SD值的影响。结果表明，利用SD值的多普勒方差成像能够区分S−-1切变率为40-60的30-55%的正常和聚集的血液，其SD值与红细胞压积无关。它也是一个敏感和可重复的聚集指标，用于比较非聚集血液样本和聚集血液样本。
We propose spectral domain Doppler optical coherence tomography (SD-D-OCT) to qualitatively measure red blood cell aggregation. Variance/standard deviation (SD) of the Doppler frequency spectrum in Doppler variance imaging of flowing blood under shearing conditions was developed as a new aggregation index. In in vitro microchannel-flow experiments, porcine blood at various hematocrits with aggregation characteristics induced by dextran 500 or at the presence of plasma fibrinogen was measured by a SD-D-OCT system with a spectrum centered at 1310 nm. The effects of shear rate, hematocrit, aggregation level on the SD values were investigated. The results demonstrate that Doppler variance imaging using the SD value was capable of differentiating the normal and the aggregated blood with hematocrits of 30–55% flowing at a shear rate of 40–60 s−1. The SD value was found to be nonsignificant hematocrit-dependent. It is also a sensitive and repeatable aggregation index for comparison between nonaggregated and aggregated blood samples.
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DOI：
10.1111/j.1749-6632.1977.tb41770.x
发表时间：
1977-01-01
影响因子：
5.2
作者：
GOLDSMITH, HL;KARINO, T
通讯作者：
KARINO, T
影响因子：
--
作者：
REINKE, W;GAEHTGENS, P;JOHNSON, PC
通讯作者：
JOHNSON, PC
影响因子：
2.3
作者：
Hard, ML;Raha, S;Koren, G
通讯作者：
Koren, G
影响因子：
20.1
作者：
TANGELDER, GJ;SLAAF, DW;RENEMAN, RS
通讯作者：
RENEMAN, RS
影响因子：
3.8
作者：
Fenech, Marianne;Garcia, Damien;Cloutier, Guy
通讯作者：
Cloutier, Guy