Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area.
Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area.
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DOI：
10.1136/bmjopen-2014-005520
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发表时间：
2014-06-12
期刊：
影响因子：
2.9
通讯作者：
Tiemeier H
中科院分区：
文献类型：
--
作者：
Ghassabian A;Steenweg-de Graaff J;Peeters RP;Ross HA;Jaddoe VW;Hofman A;Verhulst FC;White T;Tiemeier H
来自碘摄入不足人群的报告表明，母亲在怀孕期间轻度碘缺乏的儿童有认知障碍的风险。然而，目前尚不清楚，即使在碘充足的地区，低水平的碘摄入量是否会影响后代的认知发育。本研究调查了孕妇低尿碘浓度（UIC）在怀孕和儿童的认知之间的关系，在人口为基础的样本，从一个国家的最佳碘状态（荷兰）。在荷兰多种族出生队列的1525对母子中，我们调查了母亲UIC<150 μg/g肌酐（评估妊娠<18周）与儿童认知的关系。 当孩子们6岁时，在访问研究中心期间使用荷兰测试电池对非语言智商和语言理解进行了评估。 共有188名（12.3%）孕妇UIC<150 μg/g肌酐，中位UIC等于119.3 μg/g肌酐。 UIC>150 μg/g肌酐组的中位UIC为322.9 μg/g，整个样本为296.5 μg/g肌酐。 母亲低UIC和儿童的次优非语言智商之间存在单变量关联（未校正OR=1.44，95%CI 1.02至2.02）。然而，在调整混杂因素后，母亲低UIC与儿童的非语言智商无关（调整后OR=1.33，95%CI 0.92至1.93）。母亲怀孕早期的UIC与儿童6岁时的语言理解能力之间没有关系。 母亲低UIC和儿童认知之间缺乏明确的联系，这可能反映了低碘水平的发生频率和严重程度不足以影响神经发育。这可能是由于荷兰的碘强化政策，该政策允许在几乎所有加工食品中添加碘盐，并强调监测人口的碘摄入量。
Reports from populations with an insufficient iodine intake suggest that children of mothers with mild iodine deficiency during pregnancy are at risk for cognitive impairments. However, it is unknown whether, even in iodine-sufficient areas, low levels of iodine intake occur that influence cognitive development in the offspring. This study investigated the association between maternal low urinary iodine concentration (UIC) in pregnancy and children's cognition in a population-based sample from a country with an optimal iodine status (the Netherlands). In 1525 mother–child pairs in a Dutch multiethnic birth cohort, we investigated the relation between maternal UIC<150 μg/g creatinine, assessed <18 weeks gestation and children's cognition. Non-verbal IQ and language comprehension were assessed during a visit to the research centre using Dutch test batteries when the children were 6 years. In total, 188 (12.3%) pregnant women had UIC<150 μg/g creatinine, with a median UIC equal to 119.3 μg/g creatinine. The median UIC in the group with UIC>150 μg/g creatinine was 322.9 μg/g and in the whole sample 296.5 μg/g creatinine. There was a univariate association between maternal low UIC and children's suboptimum non-verbal IQ (unadjusted OR=1.44, 95% CI 1.02 to 2.02). However, after adjustment for confounders, maternal low UIC was not associated with children's non-verbal IQ (adjusted OR=1.33, 95% CI 0.92 to 1.93). There was no relation between maternal UIC in early pregnancy and children's language comprehension at 6 years. The lack of a clear association between maternal low UIC and children's cognition probably reflects that low levels of iodine were not frequent and severe enough to affect neurodevelopment. This may result from the Dutch iodine fortification policy, which allows iodised salt to be added to almost all processed food and emphasises the monitoring of iodine intake in the population.
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