SIRT2 as a Therapeutic Target for Age-Related Disorders.
SIRT2 as a Therapeutic Target for Age-Related Disorders.
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DOI：
10.3389/fphar.2012.00082
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发表时间：
2012
影响因子：
5.6
通讯作者：
Outeiro TF
中科院分区：
文献类型：
--
作者：
de Oliveira RM;Sarkander J;Kazantsev AG;Outeiro TF
Sirtuin蛋白是衰老的保守调节剂，其最近已经成为通常在生命后期发生的几种疾病（例如癌症、糖尿病、心血管和神经退行性疾病）的重要调节剂。在哺乳动物中，有七种sirtuins（SIRT 1 -7），它们在亚细胞定位和功能上表现出多样性。SIRT 1由于其对寿命的可能影响而受到广泛关注，而其他sirtuins的重要生物学和治疗作用一直被低估，最近才被认识到。在这里，我们专注于SIRT 2，sirtuin家族的成员，并讨论其在细胞和组织特异性功能的作用。本文综述了SIRT 2蛋白生物学的主要科学进展，并探讨了其作为治疗年龄相关疾病的治疗靶点的潜力。
Sirtuin proteins are conserved regulators of aging that have recently emerged as important modifiers of several diseases which commonly occur later in life such as cancer, diabetes, cardiovascular, and neurodegenerative diseases. In mammals, there are seven sirtuins (SIRT1-7), which display diversity in subcellular localization and function. SIRT1 has received much of attention due to its possible impact on longevity, while important biological and therapeutic roles of other sirtuins have been underestimated and just recently recognized. Here we focus on SIRT2, a member of the sirtuin family, and discuss its role in cellular and tissue-specific functions. This review summarizes the main scientific advances on SIRT2 protein biology and explores its potential as a therapeutic target for treatment of age-related disorders.
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影响因子：
64.8
作者：
Guarente, Leonard
通讯作者：
Guarente, Leonard
影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
DOI：
10.1006/bbrc.2000.3000
发表时间：
2000-07-05
影响因子：
3.1
作者：
Frye, RA
通讯作者：
Frye, RA
影响因子：
2.5
作者：
Iseki, E;Marui, W;Kosaka, K
通讯作者：
Kosaka, K
影响因子：
4.3
作者：
Inoue, Toshiaki;Hiratsuka, Masaharu;Oshimura, Mitsuo
通讯作者：
Oshimura, Mitsuo