Breast-feeding the last born child and risk of ovarian cancer.
Breast-feeding the last born child and risk of ovarian cancer.
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DOI：
10.1007/s10552-009-9450-8
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Cramer DW
中科院分区：
文献类型：
--
作者：
Titus-Ernstoff L;Rees JR;Terry KL;Cramer DW
关于母乳喂养和卵巢癌风险之间关系的确认报告表明，母乳喂养模式可能会产生影响。我们使用逻辑回归分析了美国新罕布什尔州和马萨诸塞州的一项卵巢癌病例对照研究中大量经产妇女的母乳喂养情况。曾母乳喂养的经产妇女卵巢癌风险降低（OR：0.75; 95%CI：0.62，0.92），但母乳喂养时间和母乳喂养儿童数量的影响证据有限。与从未母乳喂养相比，母乳喂养所有儿童（OR：0.72; 95% CI：0.58，0.91）和母乳喂养一些儿童时，最后一个出生的孩子是母乳喂养（OR：0.58; 95% CI：0.37，0.91）。几乎没有证据表明，当最后一个孩子不是母乳喂养时，母乳喂养一些孩子的风险降低（OR：0.91; 95%CI：0.66，1.26）。在有两个孩子的妇女和有两个或更多孩子的妇女中也发现了类似的结果。母乳喂养对卵巢癌风险的保护作用可能仅限于母乳喂养最后一个孩子的妇女。这些研究结果需要未来的研究来证实，这意味着母乳喂养会重置介导卵巢癌风险的妊娠相关状态。
Conflicting reports regarding the relationship between breast-feeding and ovarian cancer risk suggest a possible influence of patterns of breast-feeding. We used logistic regression to examine breast-feeding in a large population of parous women who participated in a case–control study of ovarian cancer in New Hampshire and MA, USA. Risk of ovarian cancer was reduced in parous women who ever breast-fed (OR: 0.75; 95% CI: 0.62, 0.92), but evidence was limited for an influence of duration of breast-feeding and the number of children breast-fed. Compared to never breast-feeding, inverse associations were seen for breast-feeding all children (OR: 0.72; 95% CI: 0.58, 0.91) and for breast-feeding some children when the last born child was breast-fed (OR: 0.58; 95% CI: 0.37, 0.91). There was little evidence of reduced risk for those who breast-fed some children when the last born child was not breast-fed (OR: 0.91; 95% CI: 0.66, 1.26). Similar findings were noted in women with exactly two children and in those with two or more children. The protective influence of breast-feeding on ovarian cancer risk may be limited to women who breast-feed their last born child. These findings, which require confirmation by future studies, imply that breast-feeding resets pregnancy-related states that mediate ovarian cancer risk.
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4.7
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