The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model.
The effect of rhBMP-2 and PRP delivery by biodegradable β-tricalcium phosphate scaffolds on new bone formation in a non-through rabbit cranial defect model.
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DOI：
10.1007/s10856-013-4939-9
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发表时间：
2013-08
影响因子：
3.7
通讯作者：
Park, Sang-Won
中科院分区：
文献类型：
--
作者：
Lim, Hyun-Pil;Mercado-Pagan, Angel E.;Yun, Kwi-Dug;Kang, Seong-Soo;Choi, Taek-Hue;Bishop, Julius;Koh, Jeong-Tae;Maloney, William;Lee, Kwang-Min;Yang, Yunzhi Peter;Park, Sang-Won
本研究采用兔非穿透性颅骨缺损模型，评价生物可降解β-磷酸三钙（β-TCP）支架与重组人骨形态发生蛋白-2（rhBMP-2）或富血小板血浆（PRP）联合应用是否能加速骨形成和增加骨高度。在兔颅骨上制作4个直径为8 mm的非贯通性圆柱形骨缺损。在存在和不存在浸渍的rhBMP-2或PRP的情况下，将β-TCP支架置于缺损中。在植入后8周和16周，解剖并固定样本，以通过显微计算机断层扫描和组织学进行分析。与未浸渍的β-TCP支架相比，仅rhBMP-2浸渍的β-TCP支架的缺损显示出显著增强的骨形成（p<0.05）。虽然在植入后8周新骨高于邻近骨，但在植入后16周未观察到垂直骨增加，可能是由于支架吸收与新骨形成同时发生。
This study evaluated whether the combination of biodegradable β-tricalcium phosphate (β-TCP) scaffolds with recombinant human bone morphogenetic protein-2 (rhBMP-2) or platelet-rich plasma (PRP) could accelerate bone formation and increase bone height using a rabbit non-through cranial bone defect model. Four non-through cylindrical bone defects with a diameter of 8-mm were surgically created on the cranium of rabbits. β-TCP scaffolds in the presence and absence of impregnated rhBMP-2 or PRP were placed into the defects. At 8 and 16 weeks after implantation, samples were dissected and fixed for analysis by microcomputed tomography and histology. Only defects with rhBMP-2 impregnated β-TCP scaffolds showed significantly enhanced bone formation compared to non-impregnated β-TCP scaffolds (p<0.05). Although new bone was higher than adjacent bone at 8 weeks after implantation, vertical bone augmentation was not observed at 16 weeks after implantation, probably due to scaffold resorption occurring concurrently with new bone formation.
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DOI：
10.1016/s1079-2104(98)90029-4
发表时间：
1998-06-01
影响因子：
--
作者：
Marx, RE;Carlson, ER;Georgeff, KR
通讯作者：
Georgeff, KR
影响因子：
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影响因子：
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影响因子：
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作者：
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Sencift, Kemal