Descriptive epidemiology of ependymal tumours in the United States.
Descriptive epidemiology of ependymal tumours in the United States.
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DOI：
10.1038/bjc.2013.221
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发表时间：
2013-06-11
影响因子：
8.8
通讯作者：
Dolecek TA
中科院分区：
文献类型：
--
作者：
Villano JL;Parker CK;Dolecek TA
室管膜瘤是一种罕见的原发性胶质瘤，通常影响儿童和成人，但独特的是，儿童的生存率更差。使用来自美国中央脑肿瘤登记处分析数据集的脑和中枢神经系统原发性恶性和非恶性室管膜肿瘤数据以及来自SEER 13登记处研究数据文件的原发性恶性室管膜肿瘤数据分别评价发病率和生存率。2004-2009年室管膜肿瘤的年平均年龄调整发病率为0.41/100 000。脊髓/马尾是50-60%成人室管膜肿瘤的主要诊断部位，而儿童和青少年室管膜肿瘤的诊断部位约为20%。室管膜瘤是所有年龄组中最常见的组织学类型;然而，间变性室管膜瘤在0-19岁的病例中约占30%，而在成人年龄组中约占3-5%。总的来说，相对生存率是有利的，诊断后3年和10年的生存率分别为85%和75%。然而，儿童和青少年，年龄最大的成人年龄组，诊断为间变性室管膜瘤和/或肿瘤位于大脑部位的病例的生存率最低。与成人相比，儿科病例的结局更差，原因有很多，包括间变性室管膜瘤的百分比更高，颅内疾病的病例百分比更高。
Ependymomas are rare primary gliomas that commonly affect both children and adults, but unique as survival is worse in children. Data on brain and central nervous system primary malignant and non-malignant ependymal tumours from the Central Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. The 2004–2009 average annual age-adjusted incidence rate of ependymal tumours was 0.41/100 000. Spinal cord/cauda equina was the primary site at diagnosis for 50–60% of ependymal tumours in adult age groups in contrast to about 20% in children and adolescents. Ependymoma was the most frequent histology in all age groups; however, anaplastic ependymoma comprised about 30% in cases 0–19 years of age compared with about 3–5% in adult age groups. Overall, relative survival was favourable with rates at ∼85% and 75% at 3 and 10 years post diagnosis, respectively. However, children and adolescents, the oldest adult age group, cases diagnosed with anaplastic ependymoma and/or tumour location in a brain site had lowest survival rates. Paediatric cases had worse outcomes compared with adults for numerous reasons including having a higher percentage of anaplastic ependymomas and greater percentage of cases of intracranial disease.
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影响因子：
15.9
作者：
Dolecek, Therese A.;Propp, Jennifer M.;Kruchko, Carol
通讯作者：
Kruchko, Carol
影响因子：
5.7
作者：
McCarthy, Bridget J.;Propp, Jennifer M.;Burger, Peter C.
通讯作者：
Burger, Peter C.
影响因子：
3.9
作者：
Amirian, E. Susan;Armstrong, Terri S.;Scheurer, Michael E.
通讯作者：
Scheurer, Michael E.
影响因子：
50.3
作者：
Taylor, MD;Poppleton, H;Gilbertson, RJ
通讯作者：
Gilbertson, RJ
DOI：
10.1016/0360-3016(82)90382-0
发表时间：
1982-01-01
影响因子：
7
作者：
MARKS, JE;ADLER, SJ
通讯作者：
ADLER, SJ