Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning.
Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning.
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DOI：
10.1016/j.neurobiolaging.2009.11.014
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发表时间：
2011-10
影响因子：
4.2
通讯作者：
Disterhoft JF
中科院分区：
文献类型：
--
作者：
Galvez R;Cua S;Disterhoft JF
跟踪眨眼条件反射是一种前脑依赖的学习范式，有助于我们理解与年龄相关的海马神经元可塑性;然而，海马并不被认为是大多数长期记忆存储的永久场所。对成年受试者的研究表明，新皮层就是这样一个部位。拔须研究进一步表明，新皮层的可塑性随着年龄的增长而下降。以胡须或听觉刺激作为条件刺激，对小鼠进行跟踪和延迟眨眼条件反射训练，以检查可能与年龄相关的行为和新皮层异常。胡须刺激被确定为用于检查C57小鼠中与年龄相关的行为异常的更有效的刺激。此外，新皮质桶扩张，观察到在痕迹条件的成年小鼠和兔子，不发生在小鼠条件的延迟范例或在老年小鼠无法学习胡须痕迹协会。老年人新皮质记忆储存的异常可能会导致联想学习能力的正常年龄依赖性下降。
Trace-eyeblink conditioning is a forebrain-dependent learning paradigm that has assisted in our understanding of age-related hippocampal neuronal plasticity; however, the hippocampus is not believed to be the permanent site for most long-term-memory storage. Studies in adult subjects have suggested the neocortex as one such site. Whisker plucking studies have further suggested that the ability for plasticity in the neocortex declines with age. Mice were trained in trace- and delay-eyeblink conditioning with whisker or auditory stimulation as the conditioned stimulus to examine possible age-related behavioral and neocortical abnormalities. Whisker stimulation was determined to be a more effective stimulus for examining age-related behavioral abnormalities in C57 mice. Additionally, neocortical barrel expansion, observed in trace conditioned adult mice and rabbits, does not occur in mice conditioned on a delay paradigm or in old mice unable to learn the whisker trace association. Abnormalities in neocortical memory storage in the elderly could contribute to normal age-dependent declines in associative learning abilities.
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影响因子：
3
作者：
Galvez, Roberto;Weiss, Craig;Disterhoft, John
通讯作者：
Disterhoft, John
影响因子：
2.5
作者：
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影响因子：
1.9
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影响因子：
5.3
作者：
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通讯作者：
Disterhoft, John F.
影响因子：
2.5
作者：
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通讯作者：
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