Can exercise alleviate sleep disturbances during acute nicotine withdrawal in cigarette smokers?
Can exercise alleviate sleep disturbances during acute nicotine withdrawal in cigarette smokers?
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DOI：
10.1037/pha0000390
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发表时间：
2022-03
影响因子：
2.3
通讯作者：
Kupfer DJ
中科院分区：
文献类型：
--
作者：
Soreca I;Conklin CA;Vella EJ;Salkeld RP;Joyce CJ;Mumma JM;Jakicic JM;Kupfer DJ
睡眠障碍，包括失眠（难以入睡或保持睡眠），是常见的尼古丁戒断症状，特别是在尼古丁戒断的初始阶段，并增加戒烟后前4周内复发的可能性。尽管临床上公认睡眠障碍是尼古丁戒断的关键症状，但在尼古丁依赖治疗的临床指南中并未提及。不幸的是，尼古丁替代疗法（NRT）和其他药物干预并不能减轻戒断引起的睡眠障碍，有些甚至会加剧睡眠中断。本研究测试了在尼古丁戒断的最初三天（72小时）内，每天早晨与晚上进行30分钟的适度运动对睡眠障碍的关键多导睡眠图指标的影响。49名每日吸烟者（53%男性）完成了三个独立的戒烟期，在此期间，他们完成了晨练，晚上锻炼，或非运动杂志阅读控制条件。受试者之间的条件顺序平衡，在每个3天禁欲期之间进行1周洗脱。运动参与减轻了与急性尼古丁剥夺相关的睡眠结构的一些变化和其他与时间相关的睡眠影响，特别是觉醒频率（B =-2.8，SE = 0.95; t（1271）=-3.0，p = 0.003）和睡眠维持减少（B = 0.58，SE = 0.21; t（1270）= 2.8，p = 0.005）。此外，报告更大的感知戒断严重程度的吸烟者有最长的入睡潜伏期，但在PM运动后这种影响的衰减最大。总体而言，结果表明，运动作为辅助戒烟治疗的作用，特别是针对早期急性尼古丁戒断期间的睡眠障碍。
Sleep disturbances, including insomnia (difficulty falling or staying asleep), are common nicotine withdrawal symptoms particularly during the initial stage of nicotine abstinence, and increase the likelihood of relapse within the first 4 weeks of quitting. Although clinically recognized as a key symptom of nicotine withdrawal, sleep disturbances are not addressed in the clinical guidelines for nicotine dependence treatment. Unfortunately, Nicotine Replacement Therapy (NRT) and other pharmacologic interventions do not attenuate withdrawal-provoked sleep disturbances, with several even exacerbating sleep disruption. The present study tested the impact of 30-minutes of daily moderate exercise, morning versus evening, on key polysomnographic indicators of sleep disturbances during initial three days (72 hours) of nicotine withdrawal. Forty-nine daily smokers (53% male) completed three separate abstinence periods, during which they completed either morning exercise, evening exercise, or a non-exercising magazine reading control condition. Order of condition was counterbalanced across subjects with a 1-week wash out in between each three-day abstinence period. Exercise engagement mitigated several changes in sleep architecture associated with acute nicotine deprivation and other time-related effects on sleep, specifically frequency of arousals (B = −2.8, SE = .95; t(1271) = −3.0, p = .003) and reductions in sleep maintenance (B = .58, SE = .21; t(1270) = 2.8, p = .005). Additionally, smokers who reported greater perceived withdrawal severity had the longest latency to fall asleep, but experienced the greatest attenuation of this effect following PM exercise. Overall, results suggest a role for exercise as an adjunct smoking cessation treatment to specifically target sleep disturbances during early acute nicotine withdrawal.
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影响因子：
4.8
作者：
Buman, Matthew P.;Phillips, Barbara A.;Hirshkowitz, Max
通讯作者：
Hirshkowitz, Max
DOI：
10.1152/ajpregu.00355.2002
发表时间：
2003-03-01
影响因子：
2.8
作者：
Buxton, OM;Lee, CW;Van Cauter, E
通讯作者：
Van Cauter, E
影响因子：
0.9
作者：
Ashare, Rebecca L.;Lerman, Caryn;Schnoll, Robert A.
通讯作者：
Schnoll, Robert A.
影响因子：
3.4
作者：
Jaehne, Andreas;Unbehaun, Thomas;Riemann, Dieter
通讯作者：
Riemann, Dieter
DOI：
10.1152/ajpregu.00761.2002
发表时间：
2003-06-01
影响因子：
2.8
作者：
Baehr, EK;Eastman, CI;Zee, PC
通讯作者：
Zee, PC