Brain-derived neurotrophic factor Val66Met and blood glucose: a synergistic effect on memory.
Brain-derived neurotrophic factor Val66Met and blood glucose: a synergistic effect on memory.
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DOI：
10.3389/neuro.09.012.2008
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发表时间：
2008
影响因子：
2.9
通讯作者：
Jacobs BS
中科院分区：
文献类型：
--
作者：
Raz N;Dahle CL;Rodrigue KM;Kennedy KM;Land SJ;Jacobs BS
经常报道与年龄相关的情景记忆能力下降，但其机制仍知之甚少。尽管一些遗传变异和血管危险因素与一般记忆表现和年龄差异有关，但尚不清楚它们是否以及如何改变与年龄相关的记忆衰退。为了解决这个问题，我们在健康志愿者样本（19-77 岁）中研究了影响 BDNF 分泌的脑源性神经营养因子 (BDNF) Val66Met 多态性以及空腹血糖水平（血管危险因素）对情景记忆的影响。我们发现，高龄和正常高血糖水平与姓名与面孔关联的识别记忆力下降以及散文记忆力较差有关。然而，只有 BDNF 66Met 等位基因携带者的血糖升高才预示着记忆力得分较低。对联想记忆的影响比对自由回忆的影响更强。这些发现表明，即使是低水平的血管风险也会对遗传易感个体产生负面的认知影响。减轻此类人群可治疗的血管风险可能对与年龄相关的认知能力下降产生积极影响。
Age-related declines in episodic memory performance are frequently reported, but their mechanisms remain poorly understood. Although several genetic variants and vascular risk factors have been linked to mnemonic performance in general and age differences therein, it is unknown whether and how they modify age-related memory declines. To address that question, we investigated the effect of Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism that affects secretion of BDNF, and fasting blood glucose level (a vascular risk factor) on episodic memory in a sample of healthy volunteers (age 19–77). We found that advanced age and high-normal blood glucose levels were associated with reduced recognition memory for name-face associations and poorer prose recall. However, elevated blood glucose predicted lower memory scores only in carriers of the BDNF 66Met allele. The effect on associative memory was stronger than on free recall. These findings indicate that even low-level vascular risk can produce negative cognitive effects in genetically susceptible individuals. Alleviation of treatable vascular risks in such persons may have a positive effect on age-related cognitive declines.
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影响因子：
2.6
作者：
Goldberg, Terry E.;Iudicello, Jennifer;Weinberger, Daniel R.
通讯作者：
Weinberger, Daniel R.
影响因子：
5.3
作者：
Hariri, AR;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
4.2
作者：
Craft, S
通讯作者：
Craft, S
影响因子：
2.9
作者：
Bath, KG;Lee, FS
通讯作者：
Lee, FS
DOI：
10.1002/ajmg.b.30150
发表时间：
2005-04-05
影响因子：
2.8
作者：
Dempster, E;Toulopoulou, T;Collier, DA
通讯作者：
Collier, DA