Maternal Exposure to Cigarette Smoke during Pregnancy and Testicular Cancer in Offspring: A Systematic Review and Meta-Analysis.
Maternal Exposure to Cigarette Smoke during Pregnancy and Testicular Cancer in Offspring: A Systematic Review and Meta-Analysis.
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DOI：
10.3390/life13030618
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发表时间：
2023-02-23
期刊：
影响因子：
--
通讯作者：
Juul A
中科院分区：
文献类型：
--
作者：
Beck AL;Bräuner EV;Hauser R;Lim YH;Uldbjerg CS;Juul A
背景：母亲在怀孕期间暴露于香烟烟雾可能在后代睾丸癌的发展中起作用。需要对现有证据进行更新和全面的系统评价。目的：识别和评估母亲在怀孕期间暴露于香烟烟雾和后代睾丸癌的现有证据。方法：通过块检索方法，系统检索PubMed中的英文同行评议原始文献。如果评估母亲暴露于香烟烟雾和后代患睾丸癌的风险，则考虑出版物。结果：在识别的636条记录中，14篇文献符合综述条件，10篇文献符合荟萃分析条件。对出版物进行了质量评估。大多数纳入的出版物为病例对照研究（n = 11，79%），其余为生态学研究（n = 3，21%）。报告的完整性很高，但一半以上被认为存在潜在的偏见。趋势综合显示，纳入的出版物中有一半（n = 7）表明，母亲在怀孕期间暴露于香烟烟雾的儿子患睾丸癌的风险较高。荟萃分析生成的总体汇总风险估计值为1.00（95% CI：0.88; 1.15）（n = 10篇出版物），腺瘤（0.79，95% CI：0.59; 1.04）和非腺瘤（0.96，95% CI：0.74; 1.26）的风险较低（n = 4篇出版物）。结论：该系统性综述未提供母亲暴露于香烟烟雾与后代睾丸癌风险之间相关性的证据。总体趋势是积极的，但统计精确度较低。出版物的方法局限性鼓励基于有效暴露数据进行进一步研究。
Background: Maternal exposure to cigarette smoke in pregnancy may play a role in the development of testicular cancer in offspring. An updated and comprehensive systematic review of the available evidence is needed. Objective: To identify and evaluate current evidence on maternal exposure to cigarette smoke during pregnancy and testicular cancer in offspring. Methods: A systematic search of English peer-reviewed original literature in PubMed through a block search approach. Publications were considered if assessing maternal exposure to cigarette smoke and the risk of testicular cancer in offspring. Results: Among the 636 identified records, 14 publications were eligible for review and 10 for meta-analysis. Quality assessment of the publications was conducted. Most included publications were case-control studies (n = 11, 79%), while the remaining were ecological studies (n = 3, 21%). Completeness of reporting was high, but more than half were considered subject to potential bias. The trend synthesis showed that half (n = 7) of the included publications demonstrated a higher risk of testicular cancer in the sons of mothers exposed to cigarette smoke during pregnancy. The meta-analysis generated an overall summary risk estimate of 1.00 (95% CI: 0.88; 1.15) (n = 10 publications), with a lower risk for seminoma (0.79, 95% CI: 0.59; 1.04) and nonseminoma (0.96, 95% CI: 0.74; 1.26) (n = 4 publications). Conclusions: This systematic review did not provide evidence of an association between maternal exposure to cigarette smoke and risk of testicular cancer in offspring. An overall positive trend was suggested, but it had low statistical precision. The methodological limitations across publications encourage further research based on valid exposure data.
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影响因子：
3.9
作者：
Kjersgaard CL;Arendt LH;Ernst A;Søndergaard Lindhard M;Olsen J;Henriksen TB;Strandberg-Larsen K;Ramlau-Hansen CH
通讯作者：
Ramlau-Hansen CH
DOI：
10.3390/children4010001
发表时间：
2017-01-05
期刊：
Children (Basel, Switzerland)
影响因子：
--
作者：
Giannandrea F;Fargnoli S
通讯作者：
Fargnoli S
影响因子：
5.7
作者：
Bade, Brett C.;Dela Cruz, Charles S.
通讯作者：
Dela Cruz, Charles S.
影响因子：
3.7
作者：
Kawashima A;Koide K;Ventura W;Hori K;Takenaka S;Maruyama D;Matsuoka R;Ichizuka K;Sekizawa A
通讯作者：
Sekizawa A
影响因子：
5
作者：
Ananth, CV;Savitz, DA;Luther, ER
通讯作者：
Luther, ER