The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.
The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.
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DOI：
10.1016/j.suronc.2017.07.011
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Baba H
中科院分区：
文献类型：
--
作者：
Mima K;Ogino S;Nakagawa S;Sawayama H;Kinoshita K;Krashima R;Ishimoto T;Imai K;Iwatsuki M;Hashimoto D;Baba Y;Sakamoto Y;Yamashita YI;Yoshida N;Chikamoto A;Ishiko T;Baba H
超过100万亿的微生物栖息在人类肠道中，在健康状况和疾病（包括癌症）中发挥重要作用。越来越多的证据表明，胃肠道中的特定细菌和细菌生态失调可以通过破坏DNA、激活致癌信号通路、产生促肿瘤代谢产物如次级胆汁酸和抑制抗肿瘤免疫来促进胃肠道肿瘤的发生和发展。其他细菌物种已被证明可以产生短链脂肪酸，如丁酸盐，可以抑制胃肠道的炎症和致癌作用。与这些证据一致，使用宏基因组分析的临床研究已经显示特定细菌和细菌生态失调与胃肠道癌症（包括食管癌、胃癌和结直肠癌）的关联。新出现的数据表明，肠道细菌可以调节癌症化疗和新型靶向免疫治疗（如抗CTLA4和抗CD274治疗）的疗效、吸收过程以及胃肠道手术后并发症的发生。更好地了解肠道微生物群影响肠道肿瘤发展和进展的机制，将为通过靶向肠道微生物群为胃肠道癌症患者开发新的预防和治疗策略提供机会。
More than 100 trillion microorganisms inhabit the human intestinal tract and play important roles in health conditions and diseases, including cancer. Accumulating evidence demonstrates that specific bacteria and bacterial dysbiosis in the gastrointestinal tract can potentiate the development and progression of gastrointestinal tract neoplasms by damaging DNA, activating oncogenic signaling pathways, producing tumor-promoting metabolites such as secondary bile acids, and suppressing antitumor immunity. Other bacterial species have been shown to produce short-chain fatty acids such as butyrate, which can suppress inflammation and carcinogenesis in the gastrointestinal tract. Consistent with these lines of evidence, clinical studies using metagenomic analyses have shown associations of specific bacteria and bacterial dysbiosis with gastrointestinal tract cancers, including esophageal, gastric, and colorectal cancers. Emerging data demonstrate that intestinal bacteria can modulate the efficacy of cancer chemotherapies and novel targeted immunotherapies such as anti-CTLA4 and anti-CD274 therapies, the process of absorption, and the occurrence of complications after gastrointestinal surgery. A better understanding of the mechanisms by which the gut microbiota influence tumor development and progression in the intestine would provide opportunities to develop new prevention and treatment strategies for patients with gastrointestinal tract cancers by targeting the intestinal microflora.
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影响因子：
16.6
作者：
Arthur, Janelle C.;Gharaibeh, Raad Z.;Muehlbauer, Marcus;Perez-Chanona, Ernesto;Uronis, Joshua M.;McCafferty, Jonathan;Fodor, Anthony A.;Jobin, Christian
通讯作者：
Jobin, Christian
影响因子：
4.6
作者：
Aviles-Jimenez F;Vazquez-Jimenez F;Medrano-Guzman R;Mantilla A;Torres J
通讯作者：
Torres J
影响因子：
24.5
作者：
Buda, A;Qualtrough, D;Pignatelli, M
通讯作者：
Pignatelli, M
DOI：
10.1111/j.1440-1746.2008.05490.x
发表时间：
2008-08-01
影响因子：
4.1
作者：
Balamurugan, Ramadass;Rajendiran, Ethendhar;Ramakrishna, Balakrishnan S.
通讯作者：
Ramakrishna, Balakrishnan S.
影响因子：
11.5
作者：
Bonnet, Mathilde;Buc, Emmanuel;Darfeuille-Michaud, Arlette
通讯作者：
Darfeuille-Michaud, Arlette