A Sub-millimeter, Inductively Powered Neural Stimulator.
A Sub-millimeter, Inductively Powered Neural Stimulator.
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DOI：
10.3389/fnins.2017.00659
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发表时间：
2017
影响因子：
4.3
通讯作者：
Cogan SF
中科院分区：
文献类型：
--
作者：
Freeman DK;O'Brien JM;Kumar P;Daniels B;Irion RA;Shraytah L;Ingersoll BK;Magyar AP;Czarnecki A;Wheeler J;Coppeta JR;Abban MP;Gatzke R;Fried SI;Lee SW;Duwel AE;Bernstein JJ;Widge AS;Hernandez-Reynoso A;Kanneganti A;Romero-Ortega MI;Cogan SF
无线神经刺激器正在开发中，以解决与传统铅基植入物相关的问题。然而，设计亚毫米级(1mm3)的无线刺激器是具有挑战性的。随着设备尺寸的缩小，提供足够的无线电力来操作设备变得困难。在这里，我们提出了一种亚毫米感应供电的神经刺激器，它只由一个接收能量的线圈、一个调谐接收器谐振频率的电容器和一个整流射频信号以产生神经兴奋的二极管组成。通过将任何复杂的接收器电路替换为简单的整流器，我们已将设备运行所需的电压电平从0.5到1 V(例如，对于CMOS)降低到~0.25-0.5 V。该器件封装在环氧树脂中，并在80°C的盐水中成功通过了2周的加速寿命测试。我们演示了一种基本的概念验证，使用数十微安的电流刺激大鼠的坐骨神经，以产生运动反应。
Wireless neural stimulators are being developed to address problems associated with traditional lead-based implants. However, designing wireless stimulators on the sub-millimeter scale (<1 mm3) is challenging. As device size shrinks, it becomes difficult to deliver sufficient wireless power to operate the device. Here, we present a sub-millimeter, inductively powered neural stimulator consisting only of a coil to receive power, a capacitor to tune the resonant frequency of the receiver, and a diode to rectify the radio-frequency signal to produce neural excitation. By replacing any complex receiver circuitry with a simple rectifier, we have reduced the required voltage levels that are needed to operate the device from 0.5 to 1 V (e.g., for CMOS) to ~0.25–0.5 V. This reduced voltage allows the use of smaller receive antennas for power, resulting in a device volume of 0.3–0.5 mm3. The device was encapsulated in epoxy, and successfully passed accelerated lifetime tests in 80°C saline for 2 weeks. We demonstrate a basic proof-of-concept using stimulation with tens of microamps of current delivered to the sciatic nerve in rat to produce a motor response.
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光遗传学的历史：开发用于控制脑电路的工具。
DOI：
10.3410/b3-11
发表时间：
2011
期刊：
F1000 biology reports
影响因子：
--
作者：
Boyden ES
通讯作者：
Boyden ES
影响因子：
3.5
作者：
Gabriel, C.;Peyman, A.;Grant, E. H.
通讯作者：
Grant, E. H.
影响因子：
2.7
作者：
Cho, Sung-Hoon;Xue, Ning;Lee, Jeong-Bong
通讯作者：
Lee, Jeong-Bong
DOI：
10.3390/s151229885
发表时间：
2015-12-16
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Okabe K;Jeewan HP;Yamagiwa S;Kawano T;Ishida M;Akita I
通讯作者：
Akita I
影响因子：
7.7
作者：
Meister, Markus
通讯作者：
Meister, Markus