Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle with Breast Tissue Characteristics in Young Women.
Associations of Serum Levels of Sex Hormones in Follicular and Luteal Phases of the Menstrual Cycle with Breast Tissue Characteristics in Young Women.
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DOI：
10.1371/journal.pone.0163865
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Boyd N
中科院分区：
文献类型：
--
作者：
Linton L;Taylor M;Dunn S;Martin L;Chavez S;Stanitz G;Huszti E;Minkin S;Boyd N
在之前的研究中，我们在15-30岁的年轻女性中使用磁共振测量乳房水和脂肪，并在月经周期的卵泡期同一天采集血液进行激素分析。调整协变量后，只有血清生长激素水平和性激素结合球蛋白(SHBG)与乳汁百分比显著相关。在月经周期的卵泡期，性激素雌二醇、孕酮和睾酮与乳房中水分的百分比无关。在本研究中，我们研究了在月经周期的卵泡期和黄体期，母乳百分比与血清性激素水平之间的关系。对315名年龄在15-30岁、月经规律、月经周期规律、在过去6个月内未使用口服避孕药或其他激素的健康白人年轻女性，我们用磁共振测定乳汁的百分比，并在最近一次月经周期(卵泡期)开始的10天内采集血样进行激素分析，并在周期的第19-24天采集第二次血样。本文以19-24天血清孕酮水平(P<0.05)为指标，对225例有排卵期月经周期的受试者进行了分析。SHBG与月经周期卵泡期和黄体期的水分百分比呈正相关。总雌二醇和游离雌二醇、总睾酮和游离睾酮与卵泡期的水分百分比无关，但在有排卵周期的年轻女性中，均与黄体期的水分百分比呈负相关。我们对15-30岁年轻女性的研究结果进一步证明，乳房纤维腺组织的范围与较高的血清SHBG水平呈正相关，但与较高的性激素水平无关。
In previous work in young women aged 15–30 years we measured breast water and fat using MR and obtained blood for hormone assays on the same day in the follicular phase of the menstrual cycle. Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates. The sex hormones estradiol, progesterone and testosterone were not associated with percent water in the breast in the follicular phase of the menstrual cycle. In the present study we have examined the association of percent breast water with serum levels of sex hormones in both follicular and luteal phase of the menstrual cycle. In 315 healthy white Caucasian young women aged 15–30 with regular menstrual cycles who had not used oral contraceptives or other hormones in the previous 6 months, we used MR to determine percent breast water, and obtained blood samples for hormone assays within 10 days of the onset of the most recent menstrual cycle (follicular phase) of the cycle on the same day as the MR scan, and a second blood sample on days 19–24 of the cycle. Serum progesterone levels of > = 5 mmol/L in days 19–24 were used to define the 225 subjects with ovulatory menstrual cycles, whose data are the subject of the analyses shown here. SHBG was positively associated with percent water in both follicular and luteal phases of the menstrual cycle. Total and free estradiol and total and free testosterone were not associated with percent water in the follicular phase, but in young women with ovulatory cycles, were all negatively associated with percent water in the luteal phase. Our results from young women aged 15–30 years add to the evidence that the extent of fibroglandular tissue in the breast that is reflected in both mammographic density and breast water is associated positively with higher serum levels of SHBG, but not with higher levels of sex hormones.
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DOI：
10.1530/acta.0.1070413
发表时间：
1984-01-01
期刊：
ACTA ENDOCRINOLOGICA
影响因子：
--
作者：
APTER, D;BOLTON, NJ;VIHKO, R
通讯作者：
VIHKO, R
影响因子：
3.8
作者：
Aiello, EJ;Buist, DSM;Porter, PL
通讯作者：
Porter, PL
影响因子：
3.3
作者：
Graham, SJ;Ness, S;Bronskill, MJ
通讯作者：
Bronskill, MJ
影响因子：
3
作者：
Sprague, Brian L.;Trentham-Dietz, Amy;Sisney, Gale S.
通讯作者：
Sisney, Gale S.
影响因子：
8.8
作者：
Boyd, NF;Stone, J;Martin, LJ;Jong, R;Fishel, E;Yaffe, M;Hammond, G;Minkin, S
通讯作者：
Minkin, S