Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition.
Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition.
复制标题
DOI：
10.1016/j.neuroimage.2010.06.016
复制
发表时间：
2010-10-15
期刊：
影响因子：
5.7
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Spreng, R. Nathan;Stevens, W. Dale;Chamberlain, Jon P.;Gilmore, Adrian W.;Schacter, Daniel L.
关键词：
需要外在注意的任务可靠地抑制默认的网络活动，同时激活背部注意网络。这些网络有一种内在的竞争关系；一个网络的激活会抑制另一个网络的活动。因此，许多人认为默认的网络活动在目标导向的认知过程中受到抑制。我们在一项关于规划的功能磁共振研究中挑战了这一假设。最近的研究将默认的网络活动与内部关注的认知联系起来，例如想象个人未来的事件，这表明在自传式计划中扮演了一个角色。然而，具有内部焦点的目标导向认知是如何通过这些对立的网络来调节的，目前还不清楚。在解剖学上，第三个“额顶控制网络”可能会调节跨域的计划，分别与默认注意网络或背部注意网络灵活耦合，以支持内部和外部聚焦的目标导向认知。我们通过比较自传式和视觉空间规划过程中的大脑活动来检验这一假设。自传体计划使用默认网络，而视觉空间计划使用背部注意网络，与内化和外化认知的反相关领域一致。关键的是，这两项计划任务都涉及到额顶控制网络。这三个网络的任务相关激活在解剖学上与独立定义的静息状态功能连接MRI图是一致的。总而言之，我们的发现表明，当默认网络的活动与额顶控制网络相结合时，默认网络可以参与目标定向认知。此外，额顶控制网络可以根据任务域与默认注意网络和背侧注意网络灵活地耦合，作为连接这两个网络的皮质中介，以支持目标定向的认知过程。
Tasks that demand externalized attention reliably suppress default network activity while activating the dorsal attention network. These networks have an intrinsic competitive relationship; activation of one suppresses activity of the other. Consequently, many assume that default network activity is suppressed during goal-directed cognition. We challenge this assumption in an fMRI study of planning. Recent studies link default network activity with internally focused cognition, such as imagining personal future events, suggesting a role in autobiographical planning. However, it is unclear how goal-directed cognition with an internal focus is mediated by these opposing networks. A third anatomically interposed ‘frontoparietal control network’ might mediate planning across domains, flexibly coupling with either the default or dorsal attention network in support of internally versus externally focused goal-directed cognition, respectively. We tested this hypothesis by comparing brain activity during autobiographical versus visuospatial planning. Autobiographical planning engaged the default network, whereas visuospatial planning engaged the dorsal attention network, consistent with the anti-correlated domains of internalized and externalized cognition. Critically, both planning tasks engaged the frontoparietal control network. Task-related activation of these three networks was anatomically consistent with independently defined resting-state functional connectivity MRI maps. Together, our findings suggest that the default network can be involved in goal-directed cognition when its activity is coupled with the frontoparietal control network. Additionally, the frontoparietal control network may flexibly couple with the default and dorsal attention networks according to task domain, serving as a cortical mediator linking the two networks in support of goal-directed cognitive processes.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
5.7
作者：
D'Argembeau, A;Collette, F;Salmon, E
通讯作者：
Salmon, E
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
64.8
作者：
Koechlin, E;Basso, G;Grafman, J
通讯作者：
Grafman, J