Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years.
Lifetime dog and cat exposure and dog- and cat-specific sensitization at age 18 years.
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DOI：
10.1111/j.1365-2222.2011.03747.x
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Zoratti EM
中科院分区：
文献类型：
--
作者：
Wegienka G;Johnson CC;Havstad S;Ownby DR;Nicholas C;Zoratti EM
此前关于在家养狗或猫是否会导致对该宠物过敏的研究仅限于儿童早期的结果。评估 18 岁时终生接触狗和猫与对特定动物过敏之间的关联。 1987 年至 1989 年出生队列中登记参加底特律儿童过敏研究的参与者在 18 岁时进行了联系。对狗或猫的过敏定义为动物特异性 IgE ≥0.35 kU/L。童年时期的年度访谈数据和 18 岁时的后续访谈数据被用来确定狗和猫的终生室内暴露情况（室内定义为动物在家里度过超过 50% 的时间）。暴露情况以多种方式考虑：第一年、年龄组和累积寿命。分别对狗和猫进行了分析。在男性中，与第一年没有养室内狗的男性相比，第一年养室内狗的男性在 18 岁时对狗过敏的风险只有一半（RR=0.50，95% 置信区间=CI 0.27, 0.92）。对于剖腹产出生的男性和女性也是如此（RR=0.33，95%CI 0.07，0.97）。总体而言，一岁内饲养室内猫的青少年对猫过敏的风险较低（RR=0.52，95% CI 0.31，0.90）。累积暴露或任何其他特定年龄的暴露均与这两种结果无关。生命的第一年是儿童时期的关键时期，室内接触狗或猫会影响对这些动物的敏感性。
Prior research about whether keeping a dog or cat in the home causes allergies to that pet has been limited to outcomes in early childhood. Evaluate the association between lifetime dog and cat exposure and allergic sensitization to the specific animal at age 18 years. Participants enrolled in the Detroit Childhood Allergy Study birth cohort in 1987–1989 were contacted at age 18 years. Sensitization to dog or cat was defined as animal-specific IgE ≥0.35 kU/L. Annual interview data from childhood and follow-up interviews at age 18 years were used to determine lifetime indoor dog and cat exposure (indoor defined as the animal spent >50% of their time in the home). Exposure was considered in various ways: first year, age groups and cumulative lifetime. Analyses were conducted separately for dogs and cats. Among males, those with an indoor dog in the first year of life had half the risk (RR=0.50, 95% confidence Interval=CI 0.27, 0.92) of being sensitized to dogs at age 18 compared to those who did not have an indoor dog in the first year. This was also true for males and females born via c-section (RR=0.33, 95%CI 0.07, 0.97). Overall, teens with an indoor cat in the first year of life had decreased risk (RR=0.52, 95% CI 0.31, 0.90) of being sensitized to cats. Neither cumulative exposure nor exposure at any other particular age was associated with either outcome. The first year of life is the critical period during childhood when indoor exposure to dogs or cats influences sensitization to these animals.
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影响因子：
168.9
作者：
Platts-Mills, T;Vaughan, J;Sporik, R
通讯作者：
Sporik, R
影响因子：
14.2
作者：
Gern, JE;Reardon, CL;Lemanske, RF
通讯作者：
Lemanske, RF
影响因子：
4.4
作者：
Bråbäck, L;Kjellman, NIM;Björkstén, B
通讯作者：
Björkstén, B
影响因子：
4.4
作者：
Hölscher, B;Frye, C;Heinrich, J
通讯作者：
Heinrich, J
影响因子：
7.7
作者：
BRUNEKREEF, B;GROOT, B;HOEK, G
通讯作者：
HOEK, G