Chitosan-Based Inverse Opals: Three-Dimensional Scaffolds with Uniform Pore Structures for Cell Culture.
Chitosan-Based Inverse Opals: Three-Dimensional Scaffolds with Uniform Pore Structures for Cell Culture.
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DOI：
10.1002/adma.200803504
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发表时间：
2009-04-15
影响因子：
29.4
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Choi, Sung-Wook;Xie, Jingwei;Xia, Younan
组织工程是一种很有前途的方法，用于开发生物替代品，再生，替换，维持或改善受损组织的功能。在组织工程的众多研究课题中，支架材料的结构和性能是材料科学和生物医学工程领域研究的热点。对于支架有许多一般要求：1）用于制造支架的材料必须是生物相容的和可生物降解的，以及来自接种细胞的积极响应; 2）支架应包含孔的网络，并且有利地为3D互连结构的形式;以及3）支架应该具有合适的机械性能以适合具体应用，包括软骨、骨、人造血管等的产生。[1]In为了产生明确定义的支架，已经提出了许多方法，包括乳液冷冻干燥、[2]高压处理、[3]微粒浸出、[4]气体发泡、[5]相分离、[6]和静电纺丝。[7]然而，这些方法中的大多数在能力和可行性方面是相当有限的。例如，静电纺丝方法很难扩展到制造真正的3D支架。许多其他方法通常导致形成不规则的孔径、形状和结构，以及差的连通性。
Tissue engineering is a promising approach to the development of biological substitutes that regenerate, replace, maintain, or improve the function of damaged tissues. Among various topics related to tissue engineering, the structures and properties of the scaffolds have been studied extensively in the context of material science and biomedical engineering. There are a number of generic requirements for the scaffold: 1) the material used for fabricating the scaffold must be biocompatible and biodegradable, together with positive responses from the seeded cells; 2) the scaffold should contain a network of pores, and favorably in the form of 3D interconnected architecture; and 3) the scaffold should have proper mechanical properties to suit the specific applications, including the generation of cartilage, bone, artificial blood vessel, among others.[1]In order to generate a well-defined scaffold, numerous methods have been proposed, including emulsion freeze drying,[2] high pressure processing,[3] particulate leaching,[4] gas foaming,[5] phase separation,[6] and electrospinning.[7] However, most of these methods are rather limited in terms of capability and feasibility. For example, the electrospinning method can hardly be extended to fabricate truly 3D scaffolds. Many of the other methods typically lead to the formation of irregular pore sizes, shapes, and structures, as well as poor connectivity.
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