Daytime eating prevents mood vulnerability in night work.
Daytime eating prevents mood vulnerability in night work.
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DOI：
10.1073/pnas.2206348119
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发表时间：
2022-09-20
影响因子：
11.1
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中科院分区：
文献类型：
--
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倒班工人抑郁和焦虑的风险要高出25%到40%，部分原因是中央生物钟与日常环境/行为周期之间的不协调，可能会对情绪和情绪健康产生负面影响。因此，需要基于证据的昼夜节律干预措施来防止轮班工作环境中的情绪脆弱性。我们使用严格控制的14天昼夜节律范式来评估与模拟白天工作（基线）相比，白天和夜间或白天只进食的模拟夜间工作期间的情绪脆弱性。与基线相比，模拟夜间工作、白天和夜间进食的抑郁样情绪水平增加了26.2%（使用错误发现率调整p值，pFDR = 0.001；效应大小r = 0.78），焦虑样情绪水平增加了16.1% (pFDR = 0.001；效应大小r = 0.47)，而白天只进食的模拟夜间工作组没有出现这种情况。重要的是，在模拟夜间工作期间，较大程度的内部昼夜节律失调与更多的抑郁样（r = 0.77; P = 0.001）和焦虑样（r = 0.67; P = 0.002）情绪水平密切相关。这些发现为以证据为基础的进餐时间干预提供了概念验证，可以防止轮班工作环境中的情绪脆弱性。未来的研究需要确定进餐时间的改变是否可以防止夜班工人的情绪脆弱。
Shift workers have a 25 to 40% higher risk of depression and anxiety partly due to a misalignment between the central circadian clock and daily environmental/behavioral cycles that may negatively affect mood and emotional well-being. Hence, evidence-based circadian interventions are required to prevent mood vulnerability in shift work settings. We used a stringently controlled 14-d circadian paradigm to assess mood vulnerability during simulated night work with either daytime and nighttime or daytime-only eating as compared with simulated day work (baseline). Simulated night work with daytime and nighttime eating increased depression-like mood levels by 26.2% (p-value adjusted using False Discovery Rates, pFDR = 0.001; effect-size r = 0.78) and anxiety-like mood levels by 16.1% (pFDR = 0.001; effect-size r = 0.47) compared to baseline, whereas this did not occur with simulated night work in the daytime-only eating group. Importantly, a larger degree of internal circadian misalignment was robustly associated with more depression-like (r = 0.77; P = 0.001) and anxiety-like (r = 0.67; P = 0.002) mood levels during simulated night work. These findings offer a proof-of-concept demonstration of an evidence-based meal timing intervention that may prevent mood vulnerability in shift work settings. Future studies are required to establish if changes in meal timing can prevent mood vulnerability in night workers.
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DOI：
10.1096/fj.202101153r
发表时间：
2022-01
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Chellappa SL;Engen PA;Naqib A;Qian J;Vujovic N;Rahman N;Green SJ;Garaulet M;Keshavarzian A;Scheer FAJL
通讯作者：
Scheer FAJL
DOI：
10.1186/s12966-021-01227-3
发表时间：
2021-11-27
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Yin W;Löf M;Chen R;Hultman CM;Fang F;Sandin S
通讯作者：
Sandin S
影响因子：
3.4
作者：
Chellappa, Sarah L.
通讯作者：
Chellappa, Sarah L.
影响因子：
4.6
作者：
Chellappa SL;Morris CJ;Scheer FAJL
通讯作者：
Scheer FAJL
影响因子：
16.2
作者：
Lustman, PJ;Anderson, RJ;Clouse, RE
通讯作者：
Clouse, RE