Malaria infected mosquitoes express enhanced attraction to human odor.
Malaria infected mosquitoes express enhanced attraction to human odor.
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DOI：
10.1371/journal.pone.0063602
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Logan JG
中科院分区：
文献类型：
--
作者：
Smallegange RC;van Gemert GJ;van de Vegte-Bolmer M;Gezan S;Takken W;Sauerwein RW;Logan JG
有很多证据表明，一些病原体操纵蚊子宿主的行为，以加强病原体的传播。然而，尚不清楚严格意义上的冈比亚按蚊与疟疾寄生虫恶性疟原虫的相互作用是否存在这种现象，恶性疟原虫是人类最重要的相互作用之一，疟疾每年造成2亿多人患病，77万多人死亡。在这里，我们证明，第一次，感染恶性疟原虫的原因改变行为反应的主机来源的嗅觉刺激在主机寻求女性安。冈比亚公司蚊子在行为实验中，我们发现恶性疟原虫感染了安。冈比亚蚊子明显比未感染的蚊子更容易被人类气味吸引。感染和未感染恶性疟原虫的蚊子都明显更多地落在散发人类皮肤气味的基质上，而不是干净的基质上。然而，显着更多的受感染的蚊子降落，并在散发人类皮肤气味的基板上探测比未感染的蚊子。这是第一次证明一个变化的安。冈比亚行为的嗅觉刺激引起的恶性疟原虫感染。我们的研究结果提供了重要信息，可用于更好地预测疟疾如何通过An在人与人之间传播。冈比亚公司女性此外，它强调了迫切需要进一步调查这种相互作用，以确定差异行为反应背后的嗅觉机制。这样做，可以确定新的有吸引力的化合物，其可以用于开发改进的蚊子诱捕器，用于监测或诱捕计划，甚至可以特异性地针对恶性疟原虫感染的An。冈比亚公司女性
There is much evidence that some pathogens manipulate the behaviour of their mosquito hosts to enhance pathogen transmission. However, it is unknown whether this phenomenon exists in the interaction of Anopheles gambiae sensu stricto with the malaria parasite, Plasmodium falciparum - one of the most important interactions in the context of humanity, with malaria causing over 200 million human cases and over 770 thousand deaths each year. Here we demonstrate, for the first time, that infection with P. falciparum causes alterations in behavioural responses to host-derived olfactory stimuli in host-seeking female An. gambiae s.s. mosquitoes. In behavioural experiments we showed that P. falciparum-infected An. gambiae mosquitoes were significantly more attracted to human odors than uninfected mosquitoes. Both P. falciparum-infected and uninfected mosquitoes landed significantly more on a substrate emanating human skin odor compared to a clean substrate. However, significantly more infected mosquitoes landed and probed on a substrate emanating human skin odor than uninfected mosquitoes. This is the first demonstration of a change of An. gambiae behaviour in response to olfactory stimuli caused by infection with P. falciparum. The results of our study provide vital information that could be used to provide better predictions of how malaria is transmitted from human being to human being by An. gambiae s.s. females. Additionally, it highlights the urgent need to investigate this interaction further to determine the olfactory mechanisms that underlie the differential behavioural responses. In doing so, new attractive compounds could be identified which could be used to develop improved mosquito traps for surveillance or trapping programmes that may even specifically target P. falciparum-infected An. gambiae s.s. females.
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影响因子：
9.8
作者：
Smith DL;McKenzie FE;Snow RW;Hay SI
通讯作者：
Hay SI
影响因子：
2.1
作者：
Smallegange, Renate C.;Knols, Bart G. J.;Takken, Willem
通讯作者：
Takken, Willem
影响因子：
4.4
作者：
Pitts RJ;Rinker DC;Jones PL;Rokas A;Zwiebel LJ
通讯作者：
Zwiebel LJ
影响因子：
2.4
作者：
PONNUDURAI, T;LENSEN, AHW;MEUWISSEN, JHET
通讯作者：
MEUWISSEN, JHET
影响因子：
3.7
作者：
Verhulst, Niels O.;Qiu, Yu Tong;Smallegange, Renate C.
通讯作者：
Smallegange, Renate C.