Advances in engineered Bacillus subtilis biofilms and spores, and their applications in bioremediation, biocatalysis, and biomaterials.
Advances in engineered Bacillus subtilis biofilms and spores, and their applications in bioremediation, biocatalysis, and biomaterials.
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工程枯草芽孢杆菌生物膜和芽孢及其在生物修复、生物催化和生物材料中的应用进展。
DOI：
10.1016/j.synbio.2021.07.002
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发表时间：
2021-09
影响因子：
4.8
通讯作者：
Zhuang Y
中科院分区：
文献类型：
--
作者：
Mohsin MZ;Omer R;Huang J;Mohsin A;Guo M;Qian J;Zhuang Y
枯草芽孢杆菌是一种常用的商业菌种，在生物工程和生物技术领域有着广泛的应用。B。枯草芽孢杆菌能够产生生物膜和孢子。生物膜是由基质包裹的多细胞群落，其包含各种组分，包括胞外多糖、蛋白质、胞外DNA和聚-γ-谷氨酸。这些生物膜抵抗环境条件，如氧化应激，因此在生物修复技术中有应用。此外，生物膜和孢子可以通过生物技术进行工程改造，以环境友好和安全地生产生物产品，如酶。芽孢杆菌耐恶劣条件和产生孢子的能力使其成为表面展示技术的合适候选者。近年来，这种物种的孢子被广泛使用，因为它通常被认为是安全的。合成生物学的进步使生物膜的重新编程成为可能，以改善其功能并提高增值产品的生产。在全球范围内，人们对工程生物传感器、生物催化剂和生物材料的生产越来越感兴趣。研究了B的弹性模量和凝胶性能。枯草杆菌生物膜已被用于开发活体材料。本文综述了B的形成。枯草杆菌生物膜和孢子。介绍了生物技术工程过程及其在生物修复和生物催化中的应用，以及B的发展方向。枯草芽孢杆菌生物膜工程。此外，B.总结了利用枯草芽孢杆菌生物膜和芽孢构建具有自我再生、自我调节和环境响应特性的功能性生物材料的研究进展。本文综述了B的生物工程研究进展。枯草芽孢杆菌生物膜和芽孢及其应用。
Bacillus subtilis is a commonly used commercial specie with broad applications in the fields of bioengineering and biotechnology. B. subtilis is capable of producing both biofilms and spores. Biofilms are matrix-encased multicellular communities that comprise various components including exopolysaccharides, proteins, extracellular DNA, and poly-γ-glutamic acid. These biofilms resist environmental conditions such as oxidative stress and hence have applications in bioremediation technologies. Furthermore, biofilms and spores can be engineered through biotechnological techniques for environmentally-friendly and safe production of bio-products such as enzymes. The ability to withstand with harsh conditions and producing spores makes Bacillus a suitable candidate for surface display technology. In recent years, the spores of such specie are widely used as it is generally regarded as safe to use. Advances in synthetic biology have enabled the reprogramming of biofilms to improve their functions and enhance the production of value-added products. Globally, there is increased interest in the production of engineered biosensors, biocatalysts, and biomaterials. The elastic modulus and gel properties of B. subtilis biofilms have been utilized to develop living materials. This review outlines the formation of B. subtilis biofilms and spores. Biotechnological engineering processes and their increasing application in bioremediation and biocatalysis, as well as the future directions of B. subtilis biofilm engineering, are discussed. Furthermore, the ability of B. subtilis biofilms and spores to fabricate functional living materials with self-regenerating, self-regulating and environmentally responsive characteristics has been summarized. This review aims to resume advances in biological engineering of B. subtilis biofilms and spores and their applications.
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影响因子：
64.5
作者：
BURBULYS, D;TRACH, KA;HOCH, JA
通讯作者：
HOCH, JA
影响因子：
3.2
作者：
Branda, SS;González-Pastor, JE;Kolter, R
通讯作者：
Kolter, R
影响因子：
5
作者：
Chen, Zhen-Min;Li, Qing;Chen, Xiang-Dong
通讯作者：
Chen, Xiang-Dong
影响因子：
3.4
作者：
Fathima, Aafreen;Rao, Jonnalagadda Raghava;Unni Nair, Balachandran
通讯作者：
Unni Nair, Balachandran
影响因子：
3.2
作者：
Eswaramoorthy, Prahathees;Duan, Daniel;Fujita, Masaya
通讯作者：
Fujita, Masaya