Regular exercise, subjective wellbeing, and internalizing problems in adolescence: causality or genetic pleiotropy?
Regular exercise, subjective wellbeing, and internalizing problems in adolescence: causality or genetic pleiotropy?
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DOI：
10.3389/fgene.2012.00004
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发表时间：
2012
影响因子：
3.7
通讯作者：
de Geus EJ
中科院分区：
文献类型：
--
作者：
Bartels M;de Moor MH;van der Aa N;Boomsma DI;de Geus EJ
本研究以遗传信息设计测试运动行为是否会对主观幸福感（SWB）和内化问题（INT）产生因果影响。如果运动对SWB和INT有因果影响，那么影响运动行为的遗传和环境因素也会影响SWB和INT。此外，在基因相同（MZ）的双胞胎中，运动较多的双胞胎也应该比运动较少的双胞胎表现出更高的SWB水平和更低的INT水平，因为排除了遗传混杂因素。这些表型的数据来自6317名青春期双胞胎和1180名非双胞胎兄弟姐妹的样本。大多数参与者有2年随访的纵向数据。运动行为在横向和纵向上与内化问题的减少和主观幸福感的增加相关（相关性范围为0.12至0.16）。横截面和纵向相关性主要由遗传因素决定，而环境因素的贡献可以忽略不计。在MZ双胞胎中，锻炼更多的双胞胎并没有表现出更少的内化问题和更高的主观幸福感。这在横切面和纵向上都有发现。我们的结论是，运动行为与较少的内化问题和较高水平的主观幸福感有关。这种关联在很大程度上反映了共同遗传因素对这些性状的影响。
This study tests in a genetically informative design whether exercise behavior causally influences subjective wellbeing (SWB) and internalizing problems (INT). If exercise causally influences SWB and INT, genetic and environmental factors influencing exercise behavior will also influence SWB and INT. Furthermore, within genetically identical (MZ) twin pairs, the twin who exercises more should also show higher levels of SWB and lower levels of INT, than the co-twin who exercises less, because genetic confounding is excluded. Data on these phenotypes were available in a sample of 6317 adolescent twins and 1180 non-twin-siblings. Most participants had longitudinal data with 2-year follow-up. Exercise behavior was cross-sectionally and longitudinally associated with fewer internalizing problems and increased SWB (correlations ranged from 0.12 to 0.16). Cross-sectional and longitudinal associations were mainly accounted for by genetic factors, whereas the contribution of environmental factors was negligible. Within MZ twin pairs, the twin who exercised more did not show fewer internalizing problems and increased SWB. This was found cross-sectionally and longitudinally. We conclude that exercise behavior is associated with fewer internalizing problems and higher levels of SWB. The association largely reflects the effects of common genetic factors on these traits.
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DOI：
10.1016/j.apmr.2007.09.026
发表时间：
2008-02-01
影响因子：
4.3
作者：
Hoffman, Martin D.;Hoffman, Debi Rufi
通讯作者：
Hoffman, Debi Rufi
影响因子：
8
作者：
Field, AE;Cheung, L;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
0.9
作者：
Bartels, Meike;van Beijsterveldtl, C. E. M. (Toos);Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
影响因子：
5
作者：
CAMACHO, TC;ROBERTS, RE;COHEN, RD
通讯作者：
COHEN, RD
影响因子：
5.5
作者：
Maia, JAR;Thomis, M;Beunen, G
通讯作者：
Beunen, G