Neural basis of working memory in ADHD: Load versus complexity.
Neural basis of working memory in ADHD: Load versus complexity.
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DOI：
10.1016/j.nicl.2021.102662
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Fassbender C
中科院分区：
文献类型：
--
作者：
Mukherjee P;Hartanto T;Iosif AM;Dixon JF;Hinshaw SP;Pakyurek M;van den Bos W;Guyer AE;McClure SM;Schweitzer JB;Fassbender C
工作记忆(WM)。负载与复杂性。多动症。功能磁共振成像。工作记忆、纹状体和小脑。工作记忆缺陷是注意力缺陷多动障碍(ADHD)的关键。然而，WM在ADHD患者中并不普遍受损。此外，ADHD患者WM缺陷的神经基础尚未确定，涉及的区域包括前额叶皮质、小脑和尾状核。这些矛盾可能与工作管理能力的概念化有关，例如负载(信息量)与操作复杂性(维护-回忆或操作)。例如，相对于神经典型(NT)个体，ADHD患者复杂的WM操作可能会受到损害，而更简单的操作则可以幸免。或者，在更高的负荷下，所有的操作都可能受到损害。在这里，我们比较了工作记忆能力的两个组成部分：负荷和操作复杂性，ADHD和NT之间，行为和神经方面的影响。我们假设WM负荷对ADHD的影响会更大，神经激活会发生改变。受试者(年龄范围12-23岁；50例ADHD(18名女性)；82名NT(41名女性))在功能性磁共振成像扫描中以向前或向后的顺序(操作复杂性)回忆三到四个物体(LOAD)。比较诊断和任务对学习成绩和神经投入的影响。在行为上，我们发现诊断和负荷之间以及诊断、负荷和复杂性之间存在显著的交互作用。在神经方面，我们在右侧纹状体发现了诊断和负荷之间的交互作用，在右侧小脑和左侧枕回发现了诊断和复杂性之间的交互作用。ADHD组较NT组在高负荷、高复杂度时表现为低激活。这为患有ADHD的青少年和年轻人提供了与WM相关的功能问题的机制(例如，学习成绩)和补救干预措施(例如，WM培训)。
Working memory (WM). Load versus Complexity. ADHD. FMRI. Working Memory Striatum and Cerebellum. Working memory (WM) deficits are key in attention deficit hyperactivity disorder (ADHD). Nevertheless, WM is not universally impaired in ADHD. Additionally, the neural basis for WM deficits in ADHD has not been conclusively established, with regions including the prefrontal cortex, cerebellum, and caudate being implicated. These contradictions may be related to conceptualizations of WM capacity, such as load (amount of information) versus operational-complexity (maintenance-recall or manipulation). For instance, relative to neurotypical (NT) individuals, complex WM operations could be impaired in ADHD, while simpler operations are spared. Alternatively, all operations may be impaired at higher loads. Here, we compared the impact of these two components of WM capacity: load and operational-complexity, between ADHD and NT, behaviorally and neurally. We hypothesized that the impact of WM load would be greater in ADHD, and the neural activation would be altered. Participants (age-range 12–23 years; 50 ADHD (18 females); 82 NT (41 females)) recalled three or four objects (load) in forward or backward order (operational-complexity) during functional magnetic resonance imaging scanning. The effects of diagnosis and task were compared on performance and neural engagement. Behaviorally, we found significant interactions between diagnosis and load, and between diagnosis, load, and complexity. Neurally, we found an interaction between diagnosis and load in the right striatum, and between diagnosis and complexity in the right cerebellum and left occipital gyrus. The ADHD group displayed hypo-activation compared to NT group during higher load and greater complexity. This informs mechanisms of functional problems related to WM in adolescents and young adults with ADHD (e.g., academic performance) and remedial interventions (e.g., WM-training).
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影响因子：
2.5
作者：
D'Esposito, M;Postle, BR;Lease, J
通讯作者：
Lease, J
影响因子：
5
作者：
Chatham CH;Badre D
通讯作者：
Badre D
影响因子：
64.3
作者：
Asherson, Philip;Buitelaar, Jan;Rohde, Luis A.
通讯作者：
Rohde, Luis A.
男孩的工作记忆能力和多动症症状：使用潜在轮廓分析检查工作记忆功能的异质性。
DOI：
10.1007/s10862-019-09762-x
发表时间：
2020-09
影响因子：
1.6
作者：
Campez M;Raiker JS;Sarver DE;Friedman LM;Orban SA;Rapport MD
通讯作者：
Rapport MD
影响因子：
--
作者：
Baldaçara, Leonardo;Borgio, João Guilherme Fiorani;Jackowski, Andrea Parolin
通讯作者：
Jackowski, Andrea Parolin