Make room for dedifferentiation.
Make room for dedifferentiation.
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作者：
Sheng XR;Matunis EL
几十年来，细胞分化或去分化的逆转一直令生物学家着迷。虽然细胞可以在培养中广泛地重新编程，但最近在脊椎动物和无脊椎动物系统中都出现了体内去分化的例子，使得在更多生理相关条件下分析这一有趣的过程成为可能。研究表明，去分化不仅发生在大规模的细胞再生过程中，而且还发生在低水平，以补充由于正常周转而丢失的干细胞。我们最近的论文展示了一种新的方法来诱导果蝇睾丸中的谱系定向干细胞子代重新分化为生殖系干细胞(GSCs)。我们还发现在这个过程中需要激活Janus激酶信号转导和转录激活因子(JAK-STAT)信号，并认为正常情况下不活动的生殖细胞获得移动性，并在干细胞维持微环境(NICE)中竞争驻留的体细胞。在这里，我们讨论我们的发现揭示了干细胞竞争和不同类型的细胞去分化的能力。
The reversal of cellular differentiation, or dedifferentiation, has fascinated biologists for many decades. While cells can be re-programmed extensively in culture, examples of in vivo dedifferentiation have recently emerged in both vertebrate and invertebrate systems, allowing for analysis of this intriguing process under more physiologically relevant conditions. Studies suggest that dedifferentiation occurs not only during large-scale cellular regeneration, but also at low levels to replenish stem cells lost due to normal turnover. Our recent paper demonstrates a novel method to induce the dedifferentiation of lineage-committed stem cell daughters back into germline stem cells (GSCs) in the Drosophila testis. We also show a requirement for activation of Janus kinase-signal transducer and activator of transcription (Jak-STAT) signaling in this process, and suggest that normally non-motile germline cells gain mobility and out-compete resident somatic cells for occupancy in the stem cell-maintaining microenvironment (niche). Here, we discuss what our findings reveal about stem cell competition and the capacity of various cell types to dedifferentiate.
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影响因子：
64.8
作者：
Voog, Justin;D'Alterio, Cecilia;Jones, D. Leanne
通讯作者：
Jones, D. Leanne
影响因子：
23.9
作者：
Jin, Zhigang;Kirilly, Daniel;Xie, Ting
通讯作者：
Xie, Ting
DOI：
10.1126/science.1163862
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Johnston LA
通讯作者：
Johnston LA
DOI：
10.1073/pnas.0401647101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Hayashi, Y;Hayashi, M;Kobayashi, S
通讯作者：
Kobayashi, S
影响因子：
56.9
作者：
Yamashita, YM;Jones, DL;Fuller, MT
通讯作者：
Fuller, MT