Acquired antibiotic resistance genes: an overview.

Acquired antibiotic resistance genes: an overview.
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DOI:
10.3389/fmicb.2011.00203
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发表时间:
2011
影响因子:
5.2
通讯作者:
Aarts HJ
Aarts HJ
中科院分区:
生物学2区
文献类型:
--
作者:
van Hoek AH;Mevius D;Guerra B;Mullany P;Roberts AP;Aarts HJ

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在这篇综述中,概述了抗生素耐药(AR)机制,特别注意到AR基因描述到目前为止,由一个简短的介绍不同类别的抗生素的发现和作用方式。由于这篇综述仅涉及获得性耐药,因此还关注了与AR基因相关的移动的遗传元件,如质粒、转座子和整合子,它们参与了不同细菌之间抗菌决定簇的传播。
In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria.
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