Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice.
Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice.
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DOI：
10.3389/fimmu.2018.01540
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发表时间：
2018
影响因子：
7.3
通讯作者：
Karasuyama H
中科院分区：
文献类型：
--
作者：
Tabakawa Y;Ohta T;Yoshikawa S;Robinson EJ;Yamaji K;Ishiwata K;Kawano Y;Miyake K;Yamanishi Y;Ohtsu H;Adachi T;Watanabe N;Kanuka H;Karasuyama H
扁虱是食血节肢动物，可以将病原体传播给人类和动物，导致莱姆病等严重传染病。在单次或多次扁虱感染后，一些动物物种会对扁虱饲养产生抵抗力，从而降低病原体传播的风险。据报道，在感染了长角血蜱幼虫的小鼠中，肥大细胞和嗜碱性粒细胞在获得性扁虱抵抗(ATR)的表现中发挥了关键作用，但它们如何对此做出贡献仍不清楚。在这里，我们调查了他们负责ATR的产品。用抗组胺药物治疗小鼠可以消除ATR，而组胺或组胺H1受体激动剂即使在第一次感染时也减少了扁虱的摄食。与此相一致，组胺产生不足的小鼠表现出很少或没有ATR，这表明组胺在ATR表达中起着关键作用。将来自组胺充足或缺乏的肥大细胞和嗜碱性粒细胞分别过继转移到缺乏肥大细胞和嗜碱性粒细胞的受体小鼠中，结果显示，与肥大细胞衍生的组胺是局部和全身过敏反应的主要因素相反，由嗜碱性细胞而不是肥大细胞产生的组胺对ATR的表现是必不可少的。在第二次，但不是第一次，嗜碱性粒细胞聚集并聚集在表皮中，围绕着硬蜱的口部，而肥大细胞主要散布和定位在真皮中，距离硬蜱口部较远。这似乎解释了为什么嗜碱性粒细胞来源的组胺比肥大细胞来源的组胺有效得多。组胺充足但不缺乏的小鼠在第二个扁虱摄食部位出现了增厚的表皮。综上所述，从渗入皮肤的嗜碱性粒细胞而不是驻留在皮肤上的肥大细胞释放的组胺在ATR的表现中起着至关重要的作用，可能是通过促进表皮增生而抑制扁虱的进食。
Ticks are blood-feeding arthropods that can transmit pathogens to humans and animals, leading to serious infectious diseases such as Lyme disease. After single or multiple tick infestation, some animal species develop resistance to tick feeding, leading to reduced risk of pathogen transmission. In mice infested with larval Haemaphysalis longicornis ticks, both mast cells and basophils reportedly play key roles in the manifestation of acquired tick resistance (ATR), but it remains ill-defined how they contribute to it. Here, we investigated their products responsible for ATR. Treatment of mice with antihistamine abolished the ATR while histamine or histamine H1 receptor agonist reduced tick-feeding even in the first infestation. In accordance with these, mice deficient for histamine production showed little or no ATR, indicating the crucial role for histamine in the expression of ATR. Adoptive transfer of mast cells and basophils derived from histamine-sufficient or deficient mice to recipient mice lacking mast cells and basophils, respectively, revealed that histamine produced by basophils but not mast cells is essential for the manifestation of ATR, in contrast to the case of local and systemic anaphylaxis where mast cell-derived histamine is the major player. During the second but not first tick infestation, basophils accumulated and made a cluster, surrounding a tick mouthpart, in the epidermis whereas mast cells were scattered and localized mainly in the dermis, more distantly from a tick mouthpart. This appears to explain why basophil-derived histamine is much more effective than mast cell-derived one. Histamine-sufficient, but not -deficient mice showed the thickened epidermis at the second tick-feeding site. Taken together, histamine released from skin-infiltrating basophils rather than skin-resident mast cells plays a crucial role in the manifestation of ATR, perhaps through promotion of epidermal hyperplasia that may inhibit tick feeding.
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影响因子：
7.3
作者：
Ohta T;Yoshikawa S;Tabakawa Y;Yamaji K;Ishiwata K;Shitara H;Taya C;Oh-Hora M;Kawano Y;Miyake K;Yamanishi Y;Yonekawa H;Watanabe N;Kanuka H;Karasuyama H
通讯作者：
Karasuyama H
DOI：
10.1073/pnas.93.23.13316
发表时间：
1996-11-12
影响因子：
11.1
作者：
Inoue, I;Yanai, K;Watanabe, T
通讯作者：
Watanabe, T
影响因子：
4
作者：
Wikel, SK
通讯作者：
Wikel, SK
影响因子：
4.6
作者：
Maurer, M;Opitz, M;Paus, R
通讯作者：
Paus, R
DOI：
10.1080/00034983.1982.11687525
发表时间：
1982-01-01
影响因子：
--
作者：
WIKEL, SK
通讯作者：
WIKEL, SK