Cerium oxide and platinum nanoparticles protect cells from oxidant-mediated apoptosis.
Cerium oxide and platinum nanoparticles protect cells from oxidant-mediated apoptosis.
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DOI：
10.1007/s11051-011-0544-3
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发表时间：
2011-10
影响因子：
2.5
通讯作者：
Petty, Howard R.
中科院分区：
文献类型：
--
作者：
Clark, Andrea;Zhu, Aiping;Sun, Kai;Petty, Howard R.
催化纳米颗粒代表了替代或纠正患者异常酶活性的潜在临床方法。几种疾病，包括许多致盲性眼病，是由活性氧（ROS）引起的过度氧化应激引起的。氧化铈和铂纳米颗粒代表了两种潜在的治疗性纳米颗粒，可使ROS去活性化。在本研究中，我们直接比较这两类催化纳米粒子。氧化铈和铂纳米颗粒的直径分别为16±2.4 nm和1.9±0.2 nm。使用表面等离子体增强显微镜，我们发现这些纳米粒子与细胞。此外，氧化铈和铂纳米粒子表现出超氧化物歧化酶的催化活性，但没有促进溶血或细胞溶解途径在活细胞中。重要的是，氧化铈和铂纳米颗粒减少氧化剂介导的靶细胞凋亡，如通过半胱天冬酶3的活化所判断的。减少细胞凋亡的能力可能有助于维持健康的组织。
Catalytic nanoparticles represent a potential clinical approach to replace or correct aberrant enzymatic activities in patients. Several diseases, including many blinding eye diseases, are promoted by excessive oxidant stress due to reactive oxygen species (ROS). Cerium oxide and platinum nanoparticles represent two potentially therapeutic nanoparticles that de-toxify ROS. In the present study we directly compare these two classes of catalytic nanoparticles. Cerium oxide and platinum nanoparticles were found to be 16±2.4 nm and 1.9±0.2 nm in diameter, respectively. Using surface plasmon enhanced microscopy, we find that these nanoparticles associate with cells. Furthermore, cerium oxide and platinum nanoparticles demonstrated superoxide dismutase catalytic activity, but did not promote hemolytic or cytolytic pathways in living cells. Importantly, both cerium oxide and platinum nanoparticles reduce oxidant-mediated apoptosis in target cells as judged by the activation of caspase 3. The ability to diminish apoptosis may contribute to maintaining healthy tissues.
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影响因子：
3.2
作者：
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通讯作者：
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作者：
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