Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization.
Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization.
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DOI：
10.1007/s00213-014-3840-7
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发表时间：
2015-06
影响因子：
3.4
通讯作者：
Lapish, Christopher C.
中科院分区：
文献类型：
--
作者：
Janetsian, Sarine S.;Linsenbardt, David N.;Lapish, Christopher C.
关键词：
重复使用甲基苯丙胺(MA)会导致药物的激励动机特性增加，并导致认知障碍。这些行为变化在戒断后会持续一段时间，而前额叶皮质(PFC)结构和功能的神经适应对它们的表达尤为重要。然而，对反复用药引起的PFC的神经放电和振荡活动的变化缺乏了解，从而使开发新的成瘾治疗策略变得复杂。本研究的目的是评估MA敏化后认知和脑功能的变化。建立大鼠致敏模型，分别在戒断1天和30天后进行时间记忆和再认记忆测试。我们还从大鼠的前额叶内侧获取了电生理记录，并在此基础上同时测量了振荡和尖峰活动。禁食1天和30天后，观察到时间记忆受损。然而，再认记忆仅在戒酒1天后受损。在致敏大鼠(SENS)和对照大鼠(CTRL)中，注射MA可显著降低神经元的放电频率和麻醉诱发的慢振荡(SO)。观察到SO和伽马波段功率之间有很强的相关性，这在SENS动物身上是改变的。在SENS动物中，也观察到锁定在伽马振荡中的神经元数量减少。观察到的PFC功能变化可能在MA敏化引起的行为表型改变的表达中起着不可或缺的作用。
Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularly important for their expression. However, there is a weak understanding of the changes in neural firing and oscillatory activity in the PFC evoked by repeated drug use, thus complicating the development of novel treatment strategies for addiction. The purpose of the current study was to assess changes in cognitive and brain function following MA sensitization. Sensitization was induced in rats, then temporal and recognition memory were assessed after 1 or 30 days of abstinence. Electrophysiological recordings from the medial PFC were also acquired from rats whereupon simultaneous measures of oscillatory and spiking activity were examined. Impaired temporal memory was observed after 1 and 30 days of abstinence. However, recognition memory was only impaired after 1 day of abstinence. An injection of MA profoundly decreased neuronal firing rate and the anesthesia-induced slow oscillation (SO) in both sensitized (SENS) and control (CTRL) rats. Strong correlations were observed between the SO and gamma band power, which was altered in SENS animals. A decrease in the number of neurons phase-locked to the gamma oscillation was also observed in SENS animals. The changes observed in PFC function may play an integral role in the expression of the altered behavioral phenotype evoked by MA sensitization.
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