Cross-Neutralizing Activity Against SARS-CoV-2 Variants in COVID-19 Patients: Comparison of 4 Waves of the Pandemic in Japan.
Cross-Neutralizing Activity Against SARS-CoV-2 Variants in COVID-19 Patients: Comparison of 4 Waves of the Pandemic in Japan.
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DOI：
10.1093/ofid/ofab430
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发表时间：
2021-10
影响因子：
4.2
通讯作者：
Mori Y
中科院分区：
文献类型：
--
作者：
Furukawa K;Tjan LH;Sutandhio S;Kurahashi Y;Iwata S;Tohma Y;Sano S;Nakamura S;Nishimura M;Arii J;Kiriu T;Yamamoto M;Nagano T;Nishimura Y;Mori Y
截至2021年3月，日本正面临第四波严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染。为了防止感染的进一步传播，以前感染过传统SARS-CoV-2的患者的血清对新变体的交叉中和活性很重要，但尚未确定。我们使用SARS-CoV-2 D 614 G、B.1.1.7、P.1和B.1.351变异株的真实病毒，研究了第一至第四波大流行期间81名2019冠状病毒病（COVID-19）患者血清对这些变异株的中和效力。大多数血清对所有变体都具有中和活性，对B.1.1.7和D 614 G显示出相似的活性，但活性较低，尤其是对B.1.351。在第四波中，针对B.1.1.7的血清中和活性显著高于针对包括D 614 G在内的任何其他变体的血清中和活性。对于所有变体，较轻患者的血清中和活性低于较重患者。恢复期血清的交叉中和活性对所有变体有效，但对B.1.351可能较弱。在第四波中对B.1.1.7的高特异性中和活性表明病毒中的突变可能导致其刺突蛋白的构象变化，从而影响D 614 G的免疫识别。我们的研究结果表明，从COVID-19中康复的个体可以免受新出现的变异感染引起的严重程度的影响。
As of March 2021, Japan is facing a fourth wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To prevent further spread of infection, sera cross-neutralizing activity of patients previously infected with conventional SARS-CoV-2 against novel variants is important but has not been firmly established. We investigated the neutralizing potency of 81 coronavirus disease 2019 (COVID-19) patients’ sera from the first to fourth waves of the pandemic against SARS-CoV-2 D614G, B.1.1.7, P.1, and B.1.351 variants using their authentic viruses. Most sera had neutralizing activity against all variants, showing similar activity against B.1.1.7 and D614G, but lower activity especially against B.1.351. In the fourth wave, sera-neutralizing activity against B.1.1.7 was significantly higher than that against any other variants, including D614G. The sera-neutralizing activity in less severe patients was lower than that of more severe patients for all variants. The cross-neutralizing activity of convalescent sera was effective against all variants but was potentially weaker for B.1.351. The high neutralizing activity specific to B.1.1.7 in the fourth wave suggests that mutations in the virus might cause conformational change of its spike protein, which affects immune recognition of D614G. Our results indicate that individuals who recover from COVID-19 could be protected from the severity caused by infection with newly emerging variants.
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影响因子：
32.4
作者：
Moriyama S;Adachi Y;Sato T;Tonouchi K;Sun L;Fukushi S;Yamada S;Kinoshita H;Nojima K;Kanno T;Tobiume M;Ishijima K;Kuroda Y;Park ES;Onodera T;Matsumura T;Takano T;Terahara K;Isogawa M;Nishiyama A;Kawana-Tachikawa A;Shinkai M;Tachikawa N;Nakamura S;Okai T;Okuma K;Matano T;Fujimoto T;Maeda K;Ohnishi M;Wakita T;Suzuki T;Takahashi Y
通讯作者：
Takahashi Y
DOI：
10.31662/jmaj.2020-0083
发表时间：
2021-01-29
期刊：
JMA journal
影响因子：
--
作者：
Tjan LH;Nagano T;Furukawa K;Nishimura M;Arii J;Fujinaka S;Iwata S;Sano S;Tohma Y;Nishimura Y;Mori Y
通讯作者：
Mori Y
DOI：
10.1093/cid/ciab079
发表时间：
2021-12-16
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Moghadas SM;Vilches TN;Zhang K;Wells CR;Shoukat A;Singer BH;Meyers LA;Neuzil KM;Langley JM;Fitzpatrick MC;Galvani AP
通讯作者：
Galvani AP
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.5
作者：
Korber, Bette;Fischer, Will M.;Montefiori, David C.
通讯作者：
Montefiori, David C.