Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder.
Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder.
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DOI：
10.1016/j.yebeh.2013.10.004
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Mazarati A
中科院分区：
文献类型：
--
作者：
Pineda E;Jentsch JD;Shin D;Griesbach G;Sankar R;Mazarati A
注意缺陷/多动障碍(ADHD)在癫痫患者中的发病率明显高于普通人群。癫痫-ADHD共病的机制仍很大程度上尚不清楚。我们调查了大鼠慢性癫痫模型是否会产生ADHD的迹象，因此，它是否可以用于研究这种共病的机制。用匹罗卡品致痫状态诱导雄性Wistar大鼠癫痫发作。一半的动物表现出慢性ADHD样异常，特别是在偏侧反应时间任务中冲动增加和注意力减少。这些损伤与蓝斑输出中去甲肾上腺素能传递的抑制有关。另一半动物在强迫游泳试验中表现出抑郁行为，这与中缝核5-羟色胺能传递减弱是一致的。ADHD和抑郁行为似乎是相互排斥的。因此，匹罗卡品癫痫模型为复制和研究癫痫与ADHD和/或抑郁症的共病机制提供了一个系统。
Attention deficit/hyperactivity disorder (ADHD) is encountered among epilepsy patients at a significantly higher rate than in the general population. Mechanisms of epilepsy-ADHD comorbidity remain largely unknown. We investigated whether a model of chronic epilepsy in rats produces signs of ADHD, and thus, whether it can be used for studying mechanisms of this comorbidity. Epilepsy was induced in male Wistar rats via pilocarpine status epilepticus. Half of the animals exhibited chronic ADHD-like abnormalities, particularly increased impulsivity and diminished attention in the lateralized reaction time task. These impairments correlated with the suppressed noradrenergic transmission in locus coeruleus outputs. The other half of animals exhibited depressive behavior in the forced swimming test congruently with the diminished serotonergic transmission in raphe nucleus outputs. ADHD and depressive behavior appeared mutually exclusive. Therefore, pilocarpine model of epilepsy affords a system for reproducing and studying mechanisms of comorbidity between epilepsy and both ADHD and/or depression.
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影响因子：
5.6
作者：
Detour, J;Schroeder, H;Nehlig, A
通讯作者：
Nehlig, A
影响因子：
2.2
作者：
Arida, RM;Scorza, FA;Cavalheiro, EA
通讯作者：
Cavalheiro, EA
影响因子：
2.5
作者：
Herr, Natalie R.;Park, Jinwoo;Wightman, R. Mark
通讯作者：
Wightman, R. Mark
DOI：
10.1016/b978-012088554-1/50037-2
发表时间：
2006-01-01
期刊：
MODELS OF SEIZURES AND EPILEPSY
影响因子：
--
作者：
Cavalheiro, Esper A.;Naffah-Mazzacoratti, Maria G.;Leite, Joao P.
通讯作者：
Leite, Joao P.
影响因子：
2.2
作者：
Burton, LA;Harden, C
通讯作者：
Harden, C