Toll-like receptors 2 expression in mediastinal lymph node of patients with sarcoidosis.
Toll-like receptors 2 expression in mediastinal lymph node of patients with sarcoidosis.
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DOI：
10.21037/atm-20-6103
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发表时间：
2020-09
影响因子：
--
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Chen X;Zhao D;Ning Y;Zhou Y
Toll样受体（TLR）作为连接先天性免疫系统和适应性免疫系统的第一防御机制发挥着至关重要的作用。以往的研究表明TLR2参与了结节病的免疫应答。然而，TLR2在与结节病相关的纵隔淋巴结进展中的作用仍然未知。本研究旨在探讨Toll样受体2（TLR2）在结节病患者纵隔淋巴结中的表达。收集10例结节病患者和11例正常对照者的纵隔淋巴结活检标本。免疫组化法检测纵隔淋巴结中TLR2的表达。免疫组化结果显示结节病患者纵隔淋巴结中有TLR2的表达，而对照组纵隔淋巴结中几乎没有TLR2的表达。结节病组纵隔淋巴结中TLR 2的平均光密度值（124.9±24.3）显著高于对照组（92.6±35.2）（P=0.026）。结节病患者纵隔淋巴结TLR2平均光密度值与24 h尿钙水平呈正相关（R= 0.781，P =0.038）。TLR2在结节病患者纵隔淋巴结中表达上调。TLR2在纵隔淋巴结中的表达与24小时尿钙水平相关，提示TLR2可能成为疾病活动性的另一个预测因子。
Toll-like receptors (TLRs) play a vital role as a first defense mechanism linking the innate with the adaptive immune system. Prior studies showed that TLR2 participated in immune responses of sarcoidosis. However, the role of TLR2 in the progression of mediastinal lymph nodes associated with sarcoidosis is still unknown. The current study aims to investigate the expression of Toll-like receptors 2 (TLR2) in mediastinal lymph nodes of patients with sarcoidosis. Mediastinal lymph nodes biopsy specimens were collected from 10 patients with sarcoidosis and 11 normal controls. The expression of TLR2 in mediastinal lymph nodes was detected by immunohistochemistry. In mediastinal lymph nodes specimens, immunohistochemical examination revealed that expression of TLR2 could be detected in sarcoidosis patients, while it was scarcely detected in the mediastinal lymph nodes of control. The mean optical density of TLR2 in mediastinal lymph nodes of sarcoidosis was significantly higher than controls (124.9±24.3 vs. 92.6±35.2, P=0.026). Among patients with sarcoidosis, correlation analysis showed that the mean optical density of TLR2 in mediastinal lymph nodes positively correlated with the level of 24-hour urinary calcium (R=0.781, P=0.038). The expression of TLR2 was upregulated in mediastinal lymph nodes of sarcoidosis patients. The expression of TLR2 in mediastinal lymph nodes was associated with the level of 24-hour urinary calcium, suggesting that TLR2 might become another predictor of disease activity.
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