fMRI of supraspinal areas after morphine and one week pancreatic inflammation in rats.
fMRI of supraspinal areas after morphine and one week pancreatic inflammation in rats.
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DOI：
10.1016/j.neuroimage.2008.07.048
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发表时间：
2009-01-01
期刊：
影响因子：
5.7
通讯作者：
Cleeland CS
中科院分区：
文献类型：
--
作者：
Westlund KN;Vera-Portocarrero LP;Zhang L;Wei J;Quast MJ;Cleeland CS
腹痛是患者就医的主要原因，但对传递内脏疼痛的神经通路知之甚少。我们之前已经描述了向大脑传递内脏疼痛信息的途径。内脏痛是由脊髓中央管周围X层的二级神经元引起的。本研究使用增强功能磁共振成像（fMRI）检查了直接从X层接收轴突终止的一些感兴趣的大脑区域，在诱导持续炎症和行为迹象增加的大鼠胰腺炎模型之前和之后一周。成像数据分析显示，所有感兴趣的区域的MRI信号都增加，包括解剖数据预测的髓质腹内侧吻侧、中缝背、导水管周围灰质、丘脑内侧和杏仁核中央，以及丘脑外侧、扣带/脾后和顶叶皮层的增加。枕皮质在任何情况下均未激活超过阈值，并作为阴性对照。吗啡可使MRI信号减弱，纳洛酮可拮抗下脑干部位的吗啡效应。这些数据证实了这些特定区域的激活，这些区域被称为伤害信息整合位点，在对持续的有害内脏激活的行为、情感、情绪和自主反应中发挥重要作用。
Abdominal pain is a major reason patients seek medical attention yet relatively little is known about neuronal pathways relaying visceral pain. We have previously characterized pathways transmitting information to the brain about visceral pain. Visceral pain arises from second order neurons in lamina X surrounding the spinal cord central canal. Some of the brain regions of interest receiving axonal terminations directly from lamina X were examined in the present study using enhanced functional magnetic resonance imaging (fMRI) before and one week after induction of a rat pancreatitis model with persistent inflammation and behavioral signs of increased nociception. Analysis of imaging data demonstrates an increase in MRI signal for all the regions of interest selected including the rostral ventromedial medulla, dorsal raphe, periaqueductal grey, medial thalamus, and central amygdala as predicted by the anatomical data, as well as increases in the lateral thalamus, cingulate/retrosplenial and parietal cortex. Occipital cortex was not activated above threshold in any condition and served as a negative control. Morphine attenuated the MRI signal, and the morphine effect was antagonized by naloxone in lower brainstem sites. These data confirm activation of these specific regions of interest known as integration sites for nociceptive information important in behavioral, affective, emotional and autonomic responses to ongoing noxious visceral activation.
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影响因子：
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