A framework to assess the impact of number of trials on the amplitude of motor evoked potentials.
A framework to assess the impact of number of trials on the amplitude of motor evoked potentials.
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DOI：
10.1038/s41598-020-77383-6
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发表时间：
2020-12-08
影响因子：
4.6
通讯作者：
Foffani G
中科院分区：
文献类型：
--
作者：
Ammann C;Guida P;Caballero-Insaurriaga J;Pineda-Pardo JA;Oliviero A;Foffani G
经颅磁刺激（TMS）引起的运动诱发电位（MEPs）振幅是一种常见但高度可变的皮质脊髓兴奋性测量方法。最大化试验次数和最小化实验时间之间的权衡仍然是一个障碍。因此，确定应该使用多少试验是很重要的。本研究的目的不是提供可能仅在特定实验条件下有效的经验答案，而是提供一个更一般的框架，以告知在不同实验条件下使用多少试验的决定。具体来说，我们提出了一组方程，显示了试验数量如何影响单受试者MEP幅度、总体MEP幅度、假设检验和重测信度，这取决于受试者内部和受试者之间的可变性。通过解析推导了方程，用蒙特卡罗模拟进行了验证，并代表性地应用于实验数据。我们的研究结果表明，估计单受试者MEP振幅的最小试验次数在很大程度上取决于实验条件和实验者认为可接受的误差。相反，估计总体MEP幅度和假设检验明显更依赖于受试者的数量，而不是试验的数量。这些工具和结果有助于澄清试验数量对过去和未来实验的设计和可重复性的影响。
The amplitude of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) is a common yet highly variable measure of corticospinal excitability. The tradeoff between maximizing the number of trials and minimizing experimental time remains a hurdle. It is therefore important to establish how many trials should be used. The aim of this study is not to provide rule-of-thumb answers that may be valid only in specific experimental conditions, but to offer a more general framework to inform the decision about how many trials to use under different experimental conditions. Specifically, we present a set of equations that show how the number of trials affects single-subject MEP amplitude, population MEP amplitude, hypothesis testing and test–retest reliability, depending on the variability within and between subjects. The equations are derived analytically, validated with Monte Carlo simulations, and representatively applied to experimental data. Our findings show that the minimum number of trials for estimating single-subject MEP amplitude largely depends on the experimental conditions and on the error considered acceptable by the experimenter. Conversely, estimating population MEP amplitude and hypothesis testing are markedly more dependent on the number of subjects than on the number of trials. These tools and results help to clarify the impact of the number of trials in the design and reproducibility of past and future experiments.
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最佳数量的脉冲数量作为神经腔内颅磁刺激的结果度量。
DOI：
10.1016/j.clinph.2016.04.001
发表时间：
2016-08
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Chang WH;Fried PJ;Saxena S;Jannati A;Gomes-Osman J;Kim YH;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
4.6
作者：
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通讯作者：
Foffani G
影响因子：
3.7
作者：
Bastani A;Jaberzadeh S
通讯作者：
Jaberzadeh S
影响因子：
2.5
作者：
Biabani, Mana;Farrell, Michael;Jaberzadeh, Shapour
通讯作者：
Jaberzadeh, Shapour
DOI：
10.1016/j.clinph.2017.08.007
发表时间：
2017-11
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Hallett M;Di Iorio R;Rossini PM;Park JE;Chen R;Celnik P;Strafella AP;Matsumoto H;Ugawa Y
通讯作者：
Ugawa Y