Accelerometer-derived sleep measures in idiopathic dystonia: A UK Biobank cohort study.
Accelerometer-derived sleep measures in idiopathic dystonia: A UK Biobank cohort study.
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DOI：
10.1002/brb3.2933
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发表时间：
2023-09
影响因子：
3.1
通讯作者：
Peall, Kathryn J. J.
中科院分区：
文献类型：
--
作者：
Bailey, Grace A.;Wadon, Megan E. E.;Komarzynski, Sandra;Matthews, Clare;Davies, Elin Haf;Peall, Kathryn J. J.
睡眠障碍是肌张力障碍中越来越被认可的非运动特征，迄今为止报告了不同的发现。在这里，我们使用主观自我报告的睡眠症状和客观加速度计推导的睡眠测量，与对照人群相比，检查了英国生物银行推导的肌张力障碍队列的睡眠。共有241例肌张力障碍病例与964例匹配对照进行了比较，分析了自我报告的睡眠症状和使用腕戴式三轴加速度计的睡眠结构变化。与对照组相比，肌张力障碍参与者的自我报告睡眠模式较差。加速度计测量结果表明，睡眠时间较晚，在床上的时间减少，昼夜节律的变化。未观察到与疼痛的关联，仅与精神症状的有限关系。本研究证明了加速度计在肌张力障碍患者睡眠的长期评估中的实用性，用于测量干扰和对治疗的反应。与对照组相比，肌张力障碍患者的睡眠和昼夜节律改变更常见，这可能有助于临床表型。特发性肌张力障碍的加速度计衍生睡眠测量：英国生物银行队列研究。Grace A Bailey，Megan E Wadon，Sandra Komarzynski，Claare马修斯，Elin Haf Davies，Kathryn J Peall.*没有以前的研究已经检查了睡眠的特发性肌张力障碍队列使用的目标措施来自手腕佩戴加速度计。我们利用英国生物银行的大型数据集来大规模开展这项工作。比较了241例肌张力障碍患者和964例匹配对照组的数据，确定了与对照组相比，肌张力障碍患者睡眠时间较晚，卧床时间减少，昼夜节律变化，这些差异与报告的疼痛无关。
Sleep disturbance is an increasingly recognized non‐motor trait in dystonia, with varying findings reported to date. Here, we examine sleep in a UK Biobank derived dystonia cohort using subjective self‐reported sleep symptoms and objective accelerometer‐derived sleep measures, with comparison to a control population. A total of 241 dystonia cases were compared to 964 matched controls in analysis of self‐reported sleep symptoms and changes in sleep architecture using wrist‐worn triaxial accelerometers. Dystonia participants had poorer self‐reported sleep patterns compared to controls. Accelerometery measurements demonstrated later sleep times, reduced time in bed, and shifts in circadian rhythm. No association was observed with pain, and only limited relationships with psychiatric symptoms. This study demonstrates the utility of accelerometers in longer term evaluation of sleep in dystonia, for measurement of disturbance and response to treatment. Compared to controls, altered sleep and circadian rhythm were more common in dystonia patients which may contribute to the clinical phenotype. Accelerometer‐derived sleep measures in idiopathic dystonia: A UK Biobank cohort study. Grace A Bailey, Megan E Wadon, Sandra Komarzynski, Claare Matthews, Elin Haf Davies, Kathryn J Peall.* No previous studies have examined sleep in an idiopathic dystonia cohort using objectives measures derived from wrist worn accelerometers. We made us of the large UK Biobank dataset to undertake this work at scale. Data from 241 dystonia aand 964 matched controls were compared, identifying later sleep times, reduced time in bed and shifts in circadian rhythms in those diagnosed with dystonia compared to controls, with these differences independent of reported pain.
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