Cys₂/His₂ Zinc-Finger Proteins in Transcriptional Regulation of Flower Development.
Cys₂/His₂ Zinc-Finger Proteins in Transcriptional Regulation of Flower Development.
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Cys2/His2 锌指蛋白在花发育转录调控中的作用
DOI：
10.3390/ijms19092589
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发表时间：
2018-08-31
影响因子：
5.6
通讯作者：
Cao J
中科院分区：
文献类型：
--
作者：
Lyu T;Cao J
花发育是高等植物个体发育的核心，受复杂的基因调控网络控制。Cys2/His2锌指蛋白(C2H2-ZFP)是植物体内最大的转录因子家族之一，高度参与开花诱导、花器官形态发生、花粉和雌蕊成熟的转录调控。然而，C2H2-ZFP的分子机制直到最近几年才逐渐被揭示。在开花诱导过程中，C2H2-ZFP可以修饰开花位点C的染色质，从而为定量研究染色质调控引起的转录调控提供了新的见解。C2H2-ZFP参与了花器官发育中的细胞分裂和增殖，并与激素调节有关，从而揭示了一朵花是如何被划分为四个发育不同的轮生的。在这项工作中综述的研究综合了花发育的内源、激素和环境调节的信息。C2H2-ZFP的结构决定了它们作为转录调节因子的功能。研究结果表明，C2H2-ZFP在花发育过程中起着至关重要的作用。本文综述了C2H2-ZFP的结构、表达和功能的研究现状，并对其在花发育中的分子机制进行了探讨。
Flower development is the core of higher-plant ontogenesis and is controlled by complex gene regulatory networks. Cys2/His2 zinc-finger proteins (C2H2-ZFPs) constitute one of the largest transcription factor families and are highly involved in transcriptional regulation of flowering induction, floral organ morphogenesis, and pollen and pistil maturation. Nevertheless, the molecular mechanism of C2H2-ZFPs has been gradually revealed only in recent years. During flowering induction, C2H2-ZFPs can modify the chromatin of FLOWERING LOCUS C, thereby providing additional insights into the quantification of transcriptional regulation caused by chromatin regulation. C2H2-ZFPs are involved in cell division and proliferation in floral organ development and are associated with hormonal regulation, thereby revealing how a flower is partitioned into four developmentally distinct whorls. The studies reviewed in this work integrate the information from the endogenous, hormonal, and environmental regulation of flower development. The structure of C2H2-ZFPs determines their function as transcriptional regulators. The findings indicate that C2H2-ZFPs play a crucial role in flower development. In this review, we summarize the current understanding of the structure, expression, and function of C2H2-ZFPs and discuss their molecular mechanism in flower development.
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作者：
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通讯作者：
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