Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice.
Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice.
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DOI：
10.1016/j.bbr.2021.113703
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发表时间：
2022-02-15
影响因子：
2.7
通讯作者：
Wolstenholme JT
中科院分区：
文献类型：
--
作者：
Bent MAM;Pais AC;Wolstenholme JT
青少年的大脑在与奖励、成瘾和记忆密切相关的区域经历成熟。青少年饮酒比其他任何药物都多，通常是以狂欢的方式。虽然成年人也酗酒，但青少年的大脑更容易受到酒精相关损伤的影响，这是由于其正在进行的发育，这可能导致持续的行为和身体变化，包括额叶皮层髓鞘形成的差异。性别也影响乙醇代谢和成瘾进展，表明女性比男性更敏感。这项研究解决了记忆，社交，乙醇敏感性，髓鞘基因表达的变化，由于酗酒，性别和年龄。将DBA/2 J雄性和雌性暴露于间歇性酗酒乙醇（4 g/kg，i.g.）从出生后第29-42天（PND）或作为成年人从PND 64-77。在末次给药后的早期（24小时- 7天）和晚期（从3周开始）对年龄组进行行为测试。在这两个阶段收集成人前额叶皮层。青少年酒精损害晚期记忆，而成人酒精没有损害。同时，青春期男性表现出早期阶段的耐受性乙醇诱导的运动激活，而成年女性表现出耐受性在这两个阶段。成年小鼠的社会互动减少。成年乙醇降低了Mal的表达，这是一个参与髓鞘完整性的基因，在早期阶段。在晚期没有观察到髓鞘基因表达的差异。因此，青少年酗酒乙醇更严重地影响记忆和髓鞘基因表达相比，成年暴露，而成年小鼠显示乙醇诱导的减少社会互动和耐受乙醇的运动激活。
The adolescent brain undergoes maturation in areas critically involved in reward, addiction, and memory. Adolescents consume alcohol more than any other drug, typically in a binge-like manner. While adults also binge on alcohol, the adolescent brain is more susceptible to ethanol-related damages due to its ongoing development, which may result in persistent behavioral and physical changes, including differences in myelination in the frontal cortex. Sex also impacts ethanol metabolism and addiction progression, suggesting females are more sensitive than males. This study addressed memory, sociability, ethanol sensitivity, and myelin gene expression changes due to binge ethanol, sex, and age. DBA/2J males and females were exposed to intermittent binge ethanol (4 g/kg, i.g.) from postnatal day (PND) 29–42 or as adults from PND 64–77. Age groups were tested for behaviors at the early phase (24 hours – 7 days) and late phase (starting 3 weeks) after the last dose. Adult prefrontal cortex was collected at both phases. Adolescent ethanol impaired late phase memory while adult ethanol showed no impairment. Meanwhile, adolescent males showed early phase tolerance to ethanol-induced locomotor activation, while adult females showed tolerance at both phases. Adult-treated mice displayed reductions in social interaction. Adult ethanol decreased Mal expression, a gene involved in myelin integrity, at the early phase. No differences in myelin gene expression were observed at the late phase. Thus, adolescent binge ethanol more severely impacts memory and myelin gene expression compared to adult exposure, while adult mice display ethanol-induced reductions in social interaction and tolerance to ethanol’s locomotor activation.
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影响因子：
7.6
作者：
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通讯作者：
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通讯作者：
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影响因子：
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