Differentiating Cerebellar Impact on Thalamic Nuclei.
Differentiating Cerebellar Impact on Thalamic Nuclei.
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DOI：
10.1016/j.celrep.2018.04.098
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发表时间：
2018-05-29
期刊：
影响因子：
8.8
通讯作者：
Hoebeek FE
中科院分区：
文献类型：
--
作者：
Gornati SV;Schäfer CB;Eelkman Rooda OHJ;Nigg AL;De Zeeuw CI;Hoebeek FE
小脑在运动和非运动功能的协调中起作用。小脑核（CN）轴突连接到丘脑-皮层网络的各个部分，但缺乏关于小脑-丘脑连接特征的详细信息。在这里，我们评估了小脑对腹外侧（VL）、腹内侧（VM）和中央外侧（CL）丘脑的输入。共聚焦显微镜和电镜显示，与VM或CL相比，VL的CN轴突末端密度和大小增加。体外电生理记录显示，与VM或CL神经元相比，光遗传CN刺激导致VL神经元的电荷转移和动作电位放电增强，尽管配对脉冲比没有显著差异。总之，这些发现表明，CN输入对不同丘脑核神经元的影响有很大差异，这突出了小脑输出对丘脑-皮层网络不同部分的不同控制的可能性。小脑-丘脑轴突在不同的丘脑核中形成不同大小的终末。小脑-丘脑反应在不同的丘脑核中振幅不同。重复刺激抑制所有丘脑核中的小脑-丘脑反应。在这项研究中，Gornati等人证明了小脑核轴突对丘脑神经元的影响因丘脑区域而异。这些发现为了解多功能小脑如何对与其连接的许多大脑区域产生不同的影响提供了见解。
The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of cerebello-thalamic connections is lacking. Here, we assessed the cerebellar input to the ventrolateral (VL), ventromedial (VM), and centrolateral (CL) thalamus. Confocal and electron microscopy showed an increased density and size of CN axon terminals in VL compared to VM or CL. Electrophysiological recordings in vitro revealed that optogenetic CN stimulation resulted in enhanced charge transfer and action potential firing in VL neurons compared to VM or CL neurons, despite that the paired-pulse ratio was not significantly different. Together, these findings indicate that the impact of CN input onto neurons of different thalamic nuclei varies substantially, which highlights the possibility that cerebellar output differentially controls various parts of the thalamo-cortical network. Cerebello-thalamic axons form terminals of varying size in distinct thalamic nuclei Cerebello-thalamic responses vary in amplitude in distinct thalamic nuclei Repetitive stimuli depress cerebello-thalamic responses in all thalamic nuclei In this study, Gornati et al. demonstrate that the impact of cerebellar nuclei axons on thalamic neurons varies per thalamic region. These findings provide insights into how the versatile cerebellum can have a differential effect on the many brain regions that it connects to.
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影响因子：
25
作者：
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基底神经节输出到丘脑：仍然是悖论。
影响因子：
15.9
作者：
Goldberg JH;Farries MA;Fee MS
通讯作者：
Fee MS