Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence.
Neurocognitive and Psychiatric Markers for Addiction: Common vs. Specific Endophenotypes for Heroin and Amphetamine Dependence.
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DOI：
10.2174/1568026620666200131124608
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发表时间：
2020
影响因子：
3.4
通讯作者：
Vassileva J
中科院分区：
文献类型：
--
作者：
Long EC;Kaneva R;Vasilev G;Moeller FG;Vassileva J
神经认知冲动和外化/内化特征作为海洛因依赖与安非他明依赖的推定内表型的差异效用尚不清楚。本探索性研究旨在确定：(1)神经认知冲动性维度和外化/内化特征在兄弟姐妹海洛因和安非他明依赖不协调者之间是否存在相关关系；(2)这些关联中哪些是跨物质共同的，哪些是物质特异性的。“纯”海洛因和安非他明依赖个体与其未受影响的兄弟姐妹（n = 37对海洛因兄弟姐妹；n = 30对安非他明兄弟姐妹）之间的Pearson相关性在10项神经认知测量、6项外化测量和5项内化测量中进行了测试。兄弟姐妹效应进一步用回归检验。兄弟姐妹海洛因依赖不和谐与剑桥赌博任务的延迟厌恶、气球模拟风险任务的冒险行为、感觉寻求和绝望感显著相关。兄弟姐妹对安非他命依赖的不协调与剑桥赌博任务的决策质量、即时记忆任务的判别性、围棋/不围棋任务的委托错误、特质冲动性、ADHD和焦虑敏感性显著相关。冲动和外化/内化特征的维度似乎在物质依赖不一致的兄弟姐妹中聚集。冒险倾向、寻求感觉和绝望感是海洛因兄弟姐妹特有的。运动/动作冲动性、特质冲动性和焦虑敏感性对安非他明兄弟姐妹有特异性。决定/选择冲动在海洛因和安非他明的兄弟姐妹中都很常见。这些发现为神经认知冲动和外化/内化特征作为一般物质依赖和特定物质依赖的候选内表型的效用提供了初步证据。
The differential utility of neurocognitive impulsivity and externalizing/internalizing traits as putative endophenotypes for dependence on heroin vs. amphetamine is unclear. This exploratory study aims to determine: (1) whether neurocognitive impulsivity dimensions and externalizing/internalizing traits are correlated between siblings discordant for heroin and amphetamine dependence; and (2) which of these associations are common across substances and which are substance-specific. Pearson correlations between individuals with ‘pure’ heroin and amphetamine dependence and their unaffected biological siblings (n = 37 heroin sibling pairs; n = 30 amphetamine sibling pairs) were run on 10 neurocognitive measures, 6 externalizing measures, and 5 internalizing measures. Sibling pair effects were further examined using regression. Siblings discordant for heroin dependence were significantly correlated on delay aversion on the Cambridge Gambling Task, risk-taking on the Balloon Analogue Risk Task, sensation seeking, and hopelessness. Siblings discordant for amphetamine dependence were significantly correlated on the quality of decision-making on the Cambridge Gambling Task, discriminability on the Immediate Memory Task, commission errors on the Go/No Go Task, trait impulsivity, ADHD and anxiety sensitivity. Dimensions of impulsivity and externalizing/internalizing traits appear to aggregate among siblings discordant for substance dependence. Risk-taking propensity, sensation seeking and hopelessness were specific for heroin sibling pairs. Motor/action impulsivity, trait impulsivity, and anxiety sensitivity were specific to amphetamine sibling pairs. Decisional/choice impulsivity was common across both heroin and amphetamine sibling pairs. These findings provide preliminary evidence for the utility of neurocognitive impulsivity and externalizing/ internalizing traits as candidate endophenotypes for substance dependence in general and for substance-specific dependencies.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
4.7
作者：
BAGBY, RM;PARKER, JDA;TAYLOR, GJ
通讯作者：
TAYLOR, GJ
影响因子：
6
作者：
Agrawal, Arpana;Lynskey, Michael T.;Heath, Andrew C.
通讯作者：
Heath, Andrew C.
影响因子：
10.6
作者：
Ersche, Karen D.;Turton, Abigail J.;Pradhan, Shachi;Bullmore, Edward T.;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.
影响因子：
5.8
作者：
Ersche, Karen D.;Sahakian, Barbara J.
通讯作者：
Sahakian, Barbara J.