Moderating Effects of Genetic Polymorphisms on Improvements in Cognitive Impairment in Breast Cancer Survivors Participating in a 6-Week Mindfulness-Based Stress Reduction Program.
Moderating Effects of Genetic Polymorphisms on Improvements in Cognitive Impairment in Breast Cancer Survivors Participating in a 6-Week Mindfulness-Based Stress Reduction Program.
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遗传多态性对参加为期 6 周正念减压计划的乳腺癌幸存者认知障碍改善的调节作用。
DOI：
10.1177/1099800415577633
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发表时间：
2015-07
影响因子：
2.5
通讯作者：
Park, Jong Y.
中科院分区：
文献类型：
--
作者：
Lengacher, Cecile A.;Reich, Richard R.;Kip, Kevin E.;Paterson, Carly L.;Park, Hyun Y.;Ramesar, Sophia;Jim, Heather S. L.;Alinat, Carissa B.;Park, Jong Y.
关键词：
乳腺癌（BC）幸存者经常报告认知障碍，这可能受到单核苷酸多态性（snp）的影响。本研究的目的是测试特定的snp是否与乳腺癌幸存者的认知功能变化有关，以及这些多态性是否减缓了MBSR[BC]项目所带来的认知改善。从莫菲特癌症中心和南佛罗里达大学乳房健康项目招募的乳腺癌幸存者，他们完成了辅助放疗和/或化疗，随机分为6周MBSR（BC）计划（n = 37）或常规护理（n = 35）组。在基线、6周和12周时获得认知功能、人口统计学和临床病史数据。研究人员利用血样分析了来自8个已知与认知功能相关基因的10个snp。结果表明，锚蛋白重复和激酶结构域1 [ANKK1]、载脂蛋白E [APOE]、亚甲基四氢叶酸还原酶[MTHFR]和溶质载体家族6成员4 [SLC6A4] 4个基因的snp与认知障碍相关。此外，ANKK1中的rs1800497与MBSR应答的认知障碍改善显著相关（BC）。这些结果可能有助于确定哪些个体更适合正念减压（BC）或其他干预措施。
Breast cancer (BC) survivors often report cognitive impairment, which may be influenced by single-nucleotide polymorphisms (SNPs). The purpose of this study was to test whether particular SNPs were associated with changes in cognitive function in BC survivors and whether these polymorphisms moderated cognitive improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. BC survivors recruited from Moffitt Cancer Center and the University of South Florida’s Breast Health Program, who had completed adjuvant radiation and/or chemotherapy treatment, were randomized to either the 6-week MBSR(BC) program (n = 37) or usual care (UC; n = 35) group. Measures of cognitive function and demographic and clinical history data were attained at baseline and at 6 and 12 weeks. A total of 10 SNPs from eight genes known to be related to cognitive function were analyzed using blood samples. Results showed that SNPs in four genes (ankyrin repeat and kinase domain containing 1 [ANKK1], apolipoprotein E [APOE], methylenetetrahydrofolate reductase [MTHFR], and solute carrier family 6 member 4 [SLC6A4]) were associated with cognitive impairment. Further, rs1800497 in ANKK1 was significantly associated with improvements in cognitive impairment in response to MBSR(BC). These results may help to identify individuals who would be better served by MBSR(BC) or other interventions.
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影响因子：
3.7
作者：
Berryhill ME;Wiener M;Stephens JA;Lohoff FW;Coslett HB
通讯作者：
Coslett HB
影响因子：
45.3
作者：
Ahles, Tim A.;Saykin, Andrew J.;Kaufman, Peter A.
通讯作者：
Kaufman, Peter A.
影响因子：
3.1
作者：
Biegler, Kelly A.;Chaoul, M. Alejandro;Cohen, Lorenzo
通讯作者：
Cohen, Lorenzo
影响因子：
2.5
作者：
Elliott, David A.;Kim, Woojin S.;Garner, Brett
通讯作者：
Garner, Brett
影响因子：
15.1
作者：
Jim, Heather S. L.;Park, Jong Y.;Permuth-Wey, Jennifer;Rincon, Maria A.;Phillips, Kristin M.;Small, Brent J.;Jacobsen, Paul B.
通讯作者：
Jacobsen, Paul B.