Human myometrium - the ultrastructural 3D network of telocytes.
Human myometrium - the ultrastructural 3D network of telocytes.
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DOI：
10.1111/j.1582-4934.2012.01651.x
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发表时间：
2012-11
影响因子：
5.3
通讯作者：
Popescu LM
中科院分区：
文献类型：
--
作者：
Creţoiu SM;Creţoiu D;Popescu LM
最近在组织的间隙中描述了一种新型的间质细胞--端细胞（TC）（http：www.telocytes.com）。端细胞TC具有几个非常长的念珠状延伸，即端足（Tps）。然而，技术合作的职能作用尚未得到理解。连续的切片显微照片被连接起来，以捕获Tps的整个长度，通常测量几十到几百微米。除了足突（扩张）和足突体（薄节）外，Tps的超微结构特征还包括二叉分支和建立同源和异源细胞接触。端足通过3D卷积和重叠形成一个网状系统，其数量粗略估计为每1000 μm2约20个。此外，细胞外囊泡（脱落囊泡/外泌体）沿着Tps的存在表明了一种活跃的细胞间信号传导（微分子和大分子），在调节子宫收缩力方面可能具有重要意义。
Telocytes (TCs), a novel type of interstitial cells, were recently described in the interstitial space of tissues (http://www.telocytes.com). Telocytes TCs have several very long, moniliform extensions, namely telopodes (Tps). However, the functional role(s) of TCs is not yet understood. Successive photomicrographs of ultrathin sections were concatenated to capture the entire length of Tps which usually measure tens to hundreds of micrometres. Besides the podoms (dilations) and podomers (thin segments), ultrastructural features of Tps include the dichotomous branching and establishing homo- and heterocellular contacts. Telopodes make a labyrinthine system by 3D convolution and overlapping, their number being roughly estimated at approximately 20 per 1000 μm2. Moreover, the presence of extracellular vesicles (shedding vesicles/exosomes) along the Tps suggests an active intercellular signalling (micro- and macromolecules), with possible significance in regulating uterine contractility.
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影响因子：
5.3
作者：
Ceafalan L;Gherghiceanu M;Popescu LM;Simionescu O
通讯作者：
Simionescu O
影响因子：
3.6
作者：
Duquette, RA;Shmygol, A;Wray, S
通讯作者：
Wray, S
影响因子：
2
作者：
Cretoiu, D.;Cretoiu, Sanda M.;Popescu, L. M.
通讯作者：
Popescu, L. M.
影响因子：
2.7
作者：
Suciu, Laura;Popescu, Laurentiu M.;Faussone-Pellegrini, Maria-Simonetta
通讯作者：
Faussone-Pellegrini, Maria-Simonetta
影响因子：
5.3
作者：
Mandache E;Popescu LM;Gherghiceanu M
通讯作者：
Gherghiceanu M