The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding.
The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding.
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早期创伤暴露对5-羟色胺1B受体表达的影响，通过选择性放射性结合降低。
DOI：
10.1001/archgenpsychiatry.2011.91
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发表时间：
2011-09
影响因子：
--
通讯作者：
Neumeister, Alexander
中科院分区：
文献类型：
--
作者：
Murrough, James W.;Czermak, Christoph;Henry, Shannan;Nabulsi, Nabeel;Gallezot, Jean-Dominique;Gueorguieva, Ralitza;Planeta-Wilson, Beata;Krystal, John H.;Neumaier, John F.;Huang, Yiyun;Ding, Yu-Shin;Carson, Richard E.;Neumeister, Alexander
5 -羟色胺能功能障碍与创伤后应激障碍（PTSD）的发病机制有关，最近的动物模型表明，5 -羟色胺1B型受体功能的紊乱可能导致慢性焦虑。然而，5 -羟色胺1B受体在PTSD患者中的具体作用尚未被研究。利用正电子发射断层扫描和新近开发的血清素1B受体选择性放射性示踪剂研究PTSD患者、创伤暴露对照组（TC）和健康（非创伤暴露）对照组（HC）体内血清素1B受体的表达[11C]P943。静息条件下正电子发射断层扫描研究。学术和退伍军人事务医疗中心。96例患者分为3个研究组：PTSD （n=49）、TC （n=20）和HC （n=27）。利用多变量方差分析和多元回归分析研究了优先定义的边缘皮质纹状体回路的区域[11]P943结合电位（BPND）值。PTSD组和TC组的严重创伤暴露史与尾状核、杏仁核和前扣带皮层[11C]P943 BPND的显著减少有关。受试者首次创伤暴露时的年龄与低[11C]P943 BPND密切相关。发育早期的创伤暴露也与更大的创伤后应激障碍症状严重程度和严重抑郁症共病有关。这些数据表明创伤史对脑功能和PTSD表型有持久的影响。第一次创伤的早期年龄与PTSD中更明显的神经生物学和行为改变的关联表明，PTSD的病因中有发育成分。
Serotonergic dysfunction is implicated in the pathogenesis of posttraumatic stress disorder (PTSD), and recent animal models suggest that disturbances in serotonin type 1B receptor function, in particular, may contribute to chronic anxiety. However, the specific role of the serotonin type 1B receptor has not been studied in patients with PTSD. To investigate in vivo serotonin type 1B receptor expression in individuals with PTSD, trauma-exposed control participants without PTSD (TC), and healthy (non–trauma-exposed) control participants (HC) using positron emission tomography and the recently developed serotonin type 1B receptor selective radiotracer [11C]P943. Cross-sectional positron emission tomography study under resting conditions. Academic and Veterans Affairs medical centers. Ninety-six individuals in 3 study groups: PTSD (n=49), TC (n=20), and HC (n=27). Regional [11C]P943 binding potential (BPND) values in an a priori–defined limbic corticostriatal circuit investigated using multivariate analysis of variance and multiple regression analysis. A history of severe trauma exposure in the PTSD and TC groups was associated with marked reductions in [11C]P943 BPND in the caudate, the amygdala, and the anterior cingulate cortex. Participant age at first trauma exposure was strongly associated with low [11C]P943 BPND. Developmentally earlier trauma exposure also was associated with greater PTSD symptom severity and major depression comorbidity. These data suggest an enduring effect of trauma history on brain function and the phenotype of PTSD. The association of early age at first trauma and more pronounced neurobiological and behavioral alterations in PTSD suggests a developmental component in the cause of PTSD.
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影响因子：
17.7
作者：
Bonne, O;Bain, E;Charney, DS
通讯作者：
Charney, DS
影响因子：
5.3
作者：
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56.9
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4.7
作者：
BRUINVELS, AT;LANDWEHRMEYER, B;PALACIOS, JM
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PALACIOS, JM