Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis.
Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis.
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DOI：
10.1016/j.tvjl.2015.02.017
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Saif LJ
中科院分区：
文献类型：
--
作者：
Jung K;Saif LJ
PEDV的病原学和流行病学的描述。本文就PEDV的发病机制和致病机理进行了综述。证明了流行性PED与地方性PED。免疫预防作为一种预防策略进行了讨论。猪流行性腹泻病毒（PEDV）是冠状病毒科α冠状病毒属的成员，引起血清阴性新生仔猪的急性腹泻/呕吐、脱水和高死亡率。在过去的三十年里，PEDV感染在欧洲和亚洲养猪业造成了重大的经济损失，但在2013-2014年，美国、加拿大和墨西哥也报告了这种疾病。从2013年4月至今，美国的PED疫情已经导致美国猪群损失超过10%。流行性PED的消失和重新出现表明，该病毒能够从当前的疫苗接种方案、生物安全和控制系统中逃脱。地方性PED是一个重要的问题，其因多种PEDV变体的出现（或潜在输入）而加剧。流行性PEDV毒株迅速传播并导致大量猪死亡。这些菌株是高度肠致病性的，急性感染整个小肠和大肠的绒毛上皮细胞，尽管空肠和回肠是主要部位。PEDV感染引起急性、严重的萎缩性肠炎，伴有病毒血症，导致严重的腹泻和呕吐，随后是广泛的脱水，这是哺乳仔猪死亡的主要原因。因此，全面了解PEDV流行株或地方株的致病特性，对于在疫区预防和控制该病以及开发有效的疫苗是必要的。本文就PEDV的病原学、流行病学、发病机制、致病机理以及免疫预防等方面的研究进展作一综述。
The etiology and epidemiology of PEDV are described. The disease mechanisms and pathogenesis of PEDV are reviewed. Epidemic PED versus endemic PED are demonstrated. Immunoprophylaxis as a preventive strategy is discussed. Porcine epidemic diarrhea virus (PEDV), a member of the genera Alphacoronavirus in the family Coronaviridae, causes acute diarrhea/vomiting, dehydration and high mortality in seronegative neonatal piglets. For the last three decades, PEDV infection has resulted in significant economic losses in the European and Asian pig industries, but in 2013–2014 the disease was also reported in the US, Canada and Mexico. The PED epidemic in the US, from April 2013 to the present, has led to the loss of more than 10% of the US pig population. The disappearance and re-emergence of epidemic PED indicates that the virus is able to escape from current vaccination protocols, biosecurity and control systems. Endemic PED is a significant problem, which is exacerbated by the emergence (or potential importation) of multiple PEDV variants. Epidemic PEDV strains spread rapidly and cause a high number of pig deaths. These strains are highly enteropathogenic and acutely infect villous epithelial cells of the entire small and large intestines although the jejunum and ileum are the primary sites. PEDV infections cause acute, severe atrophic enteritis accompanied by viremia that leads to profound diarrhea and vomiting, followed by extensive dehydration, which is the major cause of death in nursing piglets. A comprehensive understanding of the pathogenic characteristics of epidemic or endemic PEDV strains is needed to prevent and control the disease in affected regions and to develop an effective vaccine. This review focuses on the etiology, epidemiology, disease mechanisms and pathogenesis as well as immunoprophylaxis against PEDV infection.
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影响因子：
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