Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls.
Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls.
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DOI：
10.1016/j.jpsychires.2010.03.014
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发表时间：
2010-11
影响因子：
4.8
通讯作者：
Siever LJ
中科院分区：
文献类型：
--
作者：
Perez-Rodriguez MM;Weinstein S;New AS;Bevilacqua L;Yuan Q;Zhou Z;Hodgkinson C;Goodman M;Koenigsberg HW;Goldman D;Siever LJ
冲动性攻击和边缘型人格障碍（BPD）中的多巴胺能功能降低，遗传关联研究表明多巴胺能基因在冲动性攻击和BPD中起作用。只有一项研究分析了BPD与TPH 2基因之间的关联。TPH 2“风险”单倍型已被描述为与焦虑、抑郁和自杀行为相关。我们评估了先前确定的“风险”单倍型在TPH 2基因座和BPD诊断，冲动性攻击，情感不稳定性，自杀/parasuicidal行为之间的关系，在一个良好的表征临床样本的103名健康对照（HC）和251例人格障碍（109 BPD）。Logistic回归包括抑郁，情感不稳定性和侵略得分的措施，预测“风险”单倍型进行。BPD患者中“风险”单倍型的患病率显著高于HC患者。在Logistic回归模型中，情感不稳定性是唯一显著的预测因子，83.1%的受试者被正确分类为“风险”或“非风险”单倍型携带者。我们发现先前描述的TPH 2“风险”单倍型与BPD诊断、情感不稳定性、自杀/拟自杀行为和攻击评分之间存在关联。
There is decreased serotonergic function in impulsive aggression and borderline personality disorder (BPD), and genetic association studies suggest a role of serotonergic genes in impulsive aggression and BPD. Only one study has analyzed the association between the tryptophan-hydroxylase 2 (TPH2) gene and BPD. A TPH2 “risk” haplotype has been described that is associated with anxiety, depression and suicidal behavior. We assessed the relationship between the previously identified “risk” haplotype at the TPH2 locus and BPD diagnosis, impulsive aggression, affective lability, and suicidal/parasuicidal behaviors, in a well-characterized clinical sample of 103 healthy controls (HCs) and 251 patients with personality disorders (109 with BPD). A logistic regression including measures of depression, affective lability and aggression scores in predicting “risk” haplotype was conducted. The prevalence of the “risk” haplotype was significantly higher in patients with BPD compared to HCs. Those with the “risk” haplotype have higher aggression and affect lability scores and more suicidal/parasuicidal behaviors than those without it. In the logistic regression model, affect lability was the only significant predictor and it correctly classified 83.1% of the subjects as “risk” or “non-risk” haplotype carriers. We found an association between the previously described TPH2 “risk” haplotype and BPD diagnosis, affective lability, suicidal/parasuicidal behavior, and aggression scores.
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影响因子：
11.3
作者：
Halperin, JM;Schulz, KP;Newcorn, JH
通讯作者：
Newcorn, JH
影响因子：
10.6
作者：
Coccaro, EF;Berman, ME;Hauger, RL
通讯作者：
Hauger, RL
影响因子：
1.7
作者：
Gurvits, IG;Koenigsberg, HW;Siever, LJ
通讯作者：
Siever, LJ
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W
DOI：
10.1002/ajmg.b.30168
发表时间：
2005-05-05
影响因子：
2.8
作者：
Coon, H;Dunn, D;McMahon, W
通讯作者：
McMahon, W