Elastin and the lung.
Elastin and the lung.
复制标题
弹性蛋白和肺。
作者：
B. Starcher
所有多细胞生物体的框架必须包括一些具有高拉伸强度和刚度的材料，例如骨骼和胶原蛋白，以保持形状和机械刚度，这一点至关重要。此外，还需要一种具有内在弹性的部件，可以在需要时拉伸并承受弹性反冲。这种特性是由一种不寻常的纤维蛋白提供的，这种蛋白在 150 多年前被命名为弹性蛋白。弹性蛋白纤维几乎存在于所有脊椎动物组织中，尽管只有少数组织（例如动脉、某些韧带和肺）中弹性蛋白占总蛋白的相当大的比例。食草动物的项韧带和大多数脊椎动物的主动脉含有超过 50% 的干重弹性蛋白。另一方面，肺部的弹性蛋白含量变化很大，从啮齿动物的低至 2% 到牛和人的 28%。因此，大多数对弹性蛋白进行的化学和生物学研究都使用了牛颈韧带或几个物种的升主动脉。尽管本文的主要目的是回顾弹性蛋白在肺部的作用和代谢，但大多数背景信息必须来自其他来源的弹性蛋白。然而，这些发现可以外推到肺部，因为在给定物种内，无论起源组织如何，所有弹性蛋白在化学上都是相同的。我们可以有把握地假设，所有组织中弹性蛋白代谢的要素都是相同的，尽管显然受该特定器官细胞外基质中其他成分的影响很大。
It is essential that the framework of all multicellular organisms should include some materials with high tensile strength and rigidity, such as bone and collagen, to maintain shape and mechanical rigidity. In addition, there is a requirement for a component with intrinsic elasticity that can stretch and undergo elastic recoil when required. This property is supplied by an unusual fibrous protein, which over 150 years ago was given the name elastin.Elastin fibres are present in virtually all vertebrate tissues, although it is only within a few, such as ar-teries, some ligaments, and the lung, that elastin com-prises an appreciable percentage of the total protein. The ligamentum nuchae of grazing animals and the aorta of most vertebrates contain over 50% elastin on a dryweight basis. The elastin content of lungs on the other hand is quite variable, ranging from as low as 2% in rodents up to 28% in the cow and in man. For this reason most of the chemical and biological studies that have been conducted on elastin have used either the bovine neck ligament or the ascending aorta of several species. Although the primary aim of this article is to review the role and metabolism of elastin in the lung, most of the background information must come from elastin derivedfrom other sources. The findings may, however, be extrapolated to the lung, since within a given species all elastins appear to be chemically the same, regardless of the tissue of origin. We may safely assume that the essentials of elastin metabolism are the same in all tissues, although apparently much influenced by other components in the extracellular matrix of that particular organ.
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DOI：
10.1164/arrd.1982.126.1.174
发表时间：
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期刊：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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DOI：
10.1042/bj2170581
发表时间：
1984
期刊：
The Biochemical journal
影响因子：
--
作者：
Rich,CB;Foster,JA
通讯作者：
Foster,JA
影响因子：
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作者：
A. Janoff
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