Cytokines and posthemorrhagic ventricular dilation in premature infants.
Cytokines and posthemorrhagic ventricular dilation in premature infants.
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DOI：
10.1055/s-0032-1316443
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发表时间：
2012-10
影响因子：
2
通讯作者：
Cytokine and Generic Database Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network
中科院分区：
文献类型：
--
作者：
Ambalavanan N;Carlo WA;McDonald SA;Das A;Schendel DE;Thorsen P;Hougaard DM;Skogstrand K;Higgins RD;Cytokine and Generic Database Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research Network
确定极低出生体重 (ELBW) 婴儿血液中干扰素-γ (IFN-γ)、白细胞介素-1β (IL-1β)、IL-18、肿瘤坏死因子-α (TNF-α) 和转化生长因子-β (TGFβ) 升高是否与严重脑室内出血 (IVH) 后需要分流或与轻度分级后的心室扩张相关/否 脑室内出血。在出生后第 1、3、7、14 和 21 天测量全血细胞因子。确定前 28 天的最大 IVH 等级，以及随后超声（28 天 -36 w PMA）的分流手术或心室扩张。 NICHD NRN 细胞因子研究中的 902 名存活至 36 周/出院的婴儿中，3.1% 接受过分流。在 12% 患有严重（Gr III-IV）IVH 的婴儿中，26% 患有与 TNF-α 升高相关的分流。没有 IVH (69%) 或患有 Gr I (12%) 或 II (7%) IVH 的婴儿均未接受分流，但 8.4% 出现心室扩张，与较低的 IFN-γ 和较高的 IL-18 相关。在接受分流术的严重 IVH 婴儿和发生心室扩张的无严重 IVH 的婴儿中，注意到血液细胞因子存在统计学上显着但临床上无差别的变化。血液细胞因子可能与脑损伤有关，但在临床上可能无法作为白质损伤的生物标志物。
To determine in extremely low birth weight (ELBW) infants if elevated blood inteferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-18, tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGFβ) are associated with need for shunt following severe intraventricular hemorrhage (IVH), or with ventricular dilation following milder grades /no IVH. Whole blood cytokines were measured on postnatal days 1, 3, 7, 14, and 21. Maximum IVH grade in the first 28d, and shunt surgery or ventricular dilation on subsequent ultrasound (28d -36 w PMA) were determined. Of 902 infants in the NICHD NRN Cytokine study who survived to 36w/discharge, 3.1% had shunts. Of the 12% of infants with severe (Gr III–IV) IVH, 26% had a shunt associated with elevated TNF-α. None of the infants without IVH (69%) or with Gr I (12%) or II (7%) IVH received shunts, but 8.4% developed ventricular dilation, associated with lower IFN-γ and higher IL-18. Statistically significant but clinically non-discriminatory alterations in blood cytokines were noted in infants with severe IVH who received shunts and in those without severe IVH who developed ventricular dilation. Blood cytokines are likely associated with brain injury but may not be clinically useful as biomarkers for white matter damage.
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影响因子：
5.1
作者：
Carlo, Waldemar A.;McDonald, Scott A.;Tyson, Jon E.;Stoll, Barbara J.;Ehrenkranz, Richard A.;Shankaran, Seetha;Goldberg, Ronald N.;Das, Abhik;Schendel, Diana;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Oh, William;Laptook, Abbot R.;Duara, Shahnaz;Fanaroff, Avroy A.;Donovan, Edward F.;Korones, Sheldon B.;Stevenson, David K.;Papile, Lu-Ann;Finer, Neil N.;O'Shea, T. Michael;Poindexter, Brenda B.;Wright, Linda L.;Ambalavanan, Namasivayam;Higgins, Rosemary D.
通讯作者：
Higgins, Rosemary D.
影响因子：
3.6
作者：
Schmitz, Thomas;Heep, Axel;Felderhoff-Mueser, Ursula
通讯作者：
Felderhoff-Mueser, Ursula
影响因子：
1.9
作者：
Takizawa, T;Tada, T;Uemura, K
通讯作者：
Uemura, K
影响因子：
8.3
作者：
KITAZAWA, K;TADA, T
通讯作者：
TADA, T
影响因子：
0.7
作者：
Hayashi, N;Leifer, DW;Cohen, AR
通讯作者：
Cohen, AR