Effects of the naturally-occurring disaccharides, palatinose and sucrose, on incretin secretion in healthy non-obese subjects.
Effects of the naturally-occurring disaccharides, palatinose and sucrose, on incretin secretion in healthy non-obese subjects.
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DOI：
10.1111/jdi.12045
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发表时间：
2013-05-06
影响因子：
3.2
通讯作者：
Namba M
中科院分区：
文献类型：
--
作者：
Maeda A;Miyagawa J;Miuchi M;Nagai E;Konishi K;Matsuo T;Tokuda M;Kusunoki Y;Ochi H;Murai K;Katsuno T;Hamaguchi T;Harano Y;Namba M
肠促胰岛素可能在糖尿病和肥胖症的葡萄糖代谢中发挥一些病理生理作用;尚不清楚肠促胰岛素分泌的量和模式是否随不同类型的糖而变化。为了评价两种类型的二糖对葡萄糖代谢和肠促胰岛素分泌动力学的影响，在非肥胖健康受试者摄入帕拉金糖或蔗糖后测量血浆水平。该研究是在健康参与者中进行的，他们被给予含有50 g帕拉金糖或蔗糖的溶液用于摄入。在装载前和摄入后采集血样。通过酶联免疫吸附测定法测定胰岛素、胰高血糖素和肠促胰岛素激素。当比较帕拉金糖和蔗糖摄入之间的数据时，帕拉金糖负荷后15、30和60 min的血糖值以及15和30 min的血浆胰岛素值均显著低于蔗糖负荷后的值。帕拉金糖负荷后15-90 min的总葡萄糖依赖性促胰岛素多肽血浆水平显著低于蔗糖负荷后的水平。与蔗糖负荷相比，帕拉金糖负荷下90 min时总胰高血糖素样肽-1和活性胰高血糖素样肽-1的血浆水平以及总胰高血糖素样肽-1的曲线下面积（60-120 min）显著更高。与蔗糖相比，帕拉金糖似乎对葡萄糖代谢和胰岛保护具有更有利的作用，因为其高血糖和高胰岛素血症的效力较小。
Incretins might play some pathophysiological role in glucose metabolism in diabetes and obesity; it is not clear whether or not the amount and the pattern of incretin secretion vary with different types of sugars. To evaluate the effect of two types of disaccharides on glucose metabolism and the kinetics of incretin secretion, plasma levels were measured after palatinose or sucrose ingestion in non‐obese healthy participants. The study was carried out on healthy participants who were given a solution containing 50 g of palatinose or sucrose for ingestion. Blood samples were obtained before loading and after ingestion. Insulin, glucagon and incretins hormones were measured by the enzyme‐linked immunosorbent assay method. When the data were compared between palatinose and sucrose ingestion, both plasma glucose values at 15, 30 and 60 min, and plasma insulin values at 15 and 30 min after palatinose loading were significantly lower than those after sucrose loading. Plasma levels of total glucose‐dependent insulinotropic polypeptide at 15–90 min after palatinose loading were significantly lower than those after sucrose loading. Plasma levels of total and active glucagon‐like peptide‐1 at 90 min and the area under the curve (60–120 min) of the total glucagon‐like peptide‐1 were significantly higher with palatinose‐loading than with sucrose loading. Compared with sucrose, palatinose appears to have a more favorable effect on glucose metabolism and protection of pancreatic islets as a result of less hyperglycemic and hyperinsulinemic potency.
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影响因子：
1.6
作者：
TSUJI, Y;YAMADA, K;MORIUCHI, S
通讯作者：
MORIUCHI, S
影响因子：
15.9
作者：
NAUCK, MA;HEIMESAAT, MM;CREUTZFELDT, W
通讯作者：
CREUTZFELDT, W
影响因子：
1.6
作者：
Hira, Tohru;Muramatsu, Maya;Hara, Hiroshi
通讯作者：
Hara, Hiroshi
影响因子：
2.2
作者：
OKUDA, Y;KAWAI, K;YAMASHITA, K
通讯作者：
YAMASHITA, K
影响因子：
3.6
作者：
Tonouchi, Hidekazu;Yamaji, Taketo;Sasaki, Hajime
通讯作者：
Sasaki, Hajime