Speech-induced suppression of evoked auditory fields in children who stutter.
Speech-induced suppression of evoked auditory fields in children who stutter.
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DOI：
10.1016/j.neuroimage.2010.11.026
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发表时间：
2011-02-14
期刊：
影响因子：
5.7
通讯作者：
De Nil LF
中科院分区：
文献类型：
--
作者：
Beal DS;Quraan MA;Cheyne DO;Taylor MJ;Gracco VL;De Nil LF
与被动倾听期间对相同语音的反应相比，对自我发起的语音的听觉反应受到抑制。这种现象被称为言语诱导抑制，这是一种潜在的重要反馈介导的言语运动控制过程。在早期的一项研究中，我们发现，与被动倾听相比，口吃和不口吃的成年人在主动生产过程中对语音的听觉M50和M100反应幅度都有所降低。目前还不清楚儿童对自我发起的言语运动行为的听觉反应是否受到抑制，或者这种现象在口吃儿童和不口吃儿童之间是否存在差异。由于口吃是一种发育性言语障碍，检查儿童的言语诱导抑制可能会发现口吃发病时可能存在的神经差异。我们使用脑磁图来确定儿童是否存在言语诱发抑制，并描述口吃儿童言语诱发抑制的特征。我们检查了听觉M50，因为这是在我们的儿童参与者中可重现的最早的鲁棒反应，并且最有可能反映运动与听觉的关系。口吃和不口吃的儿童都表现出言语诱导的听觉M50抑制。然而，口吃的儿童有一个延迟的听觉M50峰潜伏期元音的声音相比，儿童谁不口吃，表明他们的能力可能存在缺陷，有效地整合听觉语音信息的目的，建立语音的神经表征的声音。
Auditory responses to speech sounds that are self-initiated are suppressed compared to responses to the same speech sounds during passive listening. This phenomenon is referred to as speech-induced suppression, a potentially important feedback-mediated speech-motor control process. In an earlier study, we found that both adults who do and do not stutter demonstrated reduced amplitude of the auditory M50 and M100 responses to speech during active production relative to passive listening. It is unknown if auditory responses to self-initiated speech-motor acts are suppressed in children or if the phenomenon differs between children who do and do not stutter. As stuttering is a developmental speech disorder, examining speech-induced suppression in children may identify possible neural differences underlying stuttering close to its time of onset. We used magnetoencephalography to determine the presence of speech-induced suppression in children and to characterize the properties of speech-induced suppression in children who stutter. We examined the auditory M50 as this was the earliest robust response reproducible across our child participants and the most likely to reflect a motor-to-auditory relation. Both children who do and do not stutter demonstrated speech-induced suppression of the auditory M50. However, children who stutter had a delayed auditory M50 peak latency to vowel sounds compared to children who do not stutter indicating a possible deficiency in their ability to efficiently integrate auditory speech information for the purpose of establishing neural representations of speech sounds.
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