The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice.
The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice.
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卡路里摄入量、禁食和饮食成分对小鼠代谢健康和肠道微生物群的影响
DOI：
10.1186/s12915-021-00987-5
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发表时间：
2021-03-19
期刊：
影响因子：
5.4
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Zhang Z;Chen X;Loh YJ;Yang X;Zhang C
卡路里限制(CR)和间歇性禁食(IF)可通过部分由肠道微生物区系调节调节的过程来促进代谢健康。为了比较不同膳食结构的CR和IF对代谢健康和肠道微生物区系的影响，我们进行了一项实验，其中小鼠接受CR或IF方案，并增加一组IF对照组(IFCtrl)，其总能量摄入量与CR组没有差异。结果在正常饮食小鼠中，IFCtrl方案与CR方案在糖脂代谢方面具有相似的积极作用，但IF方案与随意组观察的结果相比几乎没有影响。IF也有改善作用，但效果不如喂食高脂饮食的CR和IFCtrl显著。此外，CR创造了一个稳定和独特的肠道微生物群落，而IF塑造的肠道微生物区系在禁食-再喂养周期中表现出动态变化。在每个周期结束时，IFCtrl小鼠的肠道微生物区系与CR小鼠相似，IF小鼠的肠道微生物区系与自由组相似。当乳杆菌OTU2丰度较高时，无论进食方式和饮食结构，相应的代谢表型均有改善，这可能是肠道微生物区系中与代谢改善呈正相关的关键菌群之一。结论进食量、饮食结构和禁食时间对代谢健康有交互作用。改变肠道微生物区系的结构和组成可能有助于对寄主代谢的有利影响。
BackgroundCalorie restriction (CR) and intermittent fasting (IF) can promote metabolic health through a process that is partially mediated by gut microbiota modulation. To compare the effects of CR and IF with different dietary structures on metabolic health and the gut microbiota, we performed an experiment in which mice were subjected to a CR or IF regimen and an additional IF control (IFCtrl) group whose total energy intake was not different from that of the CR group was included. Each regimen was included for normal chow and high-fat diet.ResultsWe showed that in normal-chow mice, the IFCtrlregimen had similar positive effects on glucose and lipid metabolism as the CR regimen, but the IF regimen showed almost no influence compared to the outcomes observed in the ad libitum group. IF also resulted in improvements, but the effects were less marked than those associate with CR and IFCtrlwhen the mice were fed a high-fat diet. Moreover, CR created a stable and unique gut microbial community, while the gut microbiota shaped by IF exhibited dynamic changes in fasting-refeeding cycles. At the end of each cycle, the gut microbiota of the IFCtrlmice was similar to that of the CR mice, and the gut microbiota of the IF mice was similar to that of the ad libitum group. When the abundance ofLactobacillus murinusOTU2 was high, the corresponding metabolic phenotype was improved regardless of eating pattern and dietary structure, which might be one of the key bacterial groups in the gut microbiota that is positively correlated with metabolic amelioration.ConclusionThere are interactions among the amount of food intake, the diet structure, and the fasting time on metabolic health. The structure and composition of gut microbiota modified by dietary regimens might contribute to the beneficial effects on the host metabolism.
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影响因子：
29
作者：
Li G;Xie C;Lu S;Nichols RG;Tian Y;Li L;Patel D;Ma Y;Brocker CN;Yan T;Krausz KW;Xiang R;Gavrilova O;Patterson AD;Gonzalez FJ
通讯作者：
Gonzalez FJ
影响因子：
--
作者：
Mitchell SE;Delville C;Konstantopedos P;Hurst J;Derous D;Green C;Chen L;Han JJ;Wang Y;Promislow DE;Lusseau D;Douglas A;Speakman JR
通讯作者：
Speakman JR
影响因子：
64.5
作者：
Fontana L;Partridge L
通讯作者：
Partridge L
热量限制小鼠中更强大的肠道微生物群与化疗药物环磷酰胺引起的肠道损伤减轻有关
影响因子：
6.4
作者：
Liu, Tao;Wu, Yanqiu;Zhang, Chenhong
通讯作者：
Zhang, Chenhong
翻转代谢开关：了解和应用禁食的健康益处。
DOI：
10.1002/oby.22065
发表时间：
2018-03
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Anton SD;Moehl K;Donahoo WT;Marosi K;Lee SA;Mainous AG 3rd;Leeuwenburgh C;Mattson MP
通讯作者：
Mattson MP