Thyroid hormone: sex-dependent role in nervous system regulation and disease.
Thyroid hormone: sex-dependent role in nervous system regulation and disease.
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DOI：
10.1186/s13293-021-00367-2
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发表时间：
2021-03-08
影响因子：
7.9
通讯作者：
Pradhan A
中科院分区：
文献类型：
--
作者：
Baksi S;Pradhan A
甲状腺激素（TH）调节许多功能，包括代谢，细胞分化和神经系统发育。体内甲状腺激素水平的改变可导致与认知、视觉注意力、视觉处理、运动技能、语言和记忆技能相关的神经系统相关问题。TH还与神经精神障碍相关，包括精神分裂症、双相情感障碍、焦虑和抑郁。男性和女性在神经元信号传导方面表现出性别特异性差异。包括睾酮和雌激素在内的类固醇激素被认为是以男性和女性特异性方式编程神经元信号的主要调节剂。然而，除了类固醇激素，TH也可能是以男性和女性特异性方式调节不同大脑信号的关键信号分子之一。甲状腺相关疾病和神经系统疾病显示出性别特异性发病率;然而，这背后的分子机制尚不清楚。因此，了解TH在男性和女性大脑中的作用以及关键基因和信号网络是什么将是非常有益的。在这篇综述中，我们强调了TH在神经系统调节和疾病结局中的作用，并特别强调了其在男性和女性大脑中的性别特异性作用。还提出了一个网络模型，提供TH调节基因，信号和疾病的关键信息。
Thyroid hormone (TH) regulates many functions including metabolism, cell differentiation, and nervous system development. Alteration of thyroid hormone level in the body can lead to nervous system-related problems linked to cognition, visual attention, visual processing, motor skills, language, and memory skills. TH has also been associated with neuropsychiatric disorders including schizophrenia, bipolar disorder, anxiety, and depression. Males and females display sex-specific differences in neuronal signaling. Steroid hormones including testosterone and estrogen are considered to be the prime regulators for programing the neuronal signaling in a male- and female-specific manner. However, other than steroid hormones, TH could also be one of the key signaling molecules to regulate different brain signaling in a male- and female-specific manner. Thyroid-related diseases and neurological diseases show sex-specific incidence; however, the molecular mechanisms behind this are not clear. Hence, it will be very beneficial to understand how TH acts in male and female brains and what are the critical genes and signaling networks. In this review, we have highlighted the role of TH in nervous system regulation and disease outcome and given special emphasis on its sex-specific role in male and female brains. A network model is also presented that provides critical information on TH-regulated genes, signaling, and disease.
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影响因子：
6.6
作者：
Cho, Byuri Angela;Yoo, Seong-Keun;Seo, Jeong-Sun
通讯作者：
Seo, Jeong-Sun
DOI：
10.1186/s13195-017-0291-5
发表时间：
2017-08-17
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Choi HJ;Byun MS;Yi D;Sohn BK;Lee JH;Lee JY;Kim YK;Lee DY;KBASE Research Group
通讯作者：
KBASE Research Group
影响因子：
3.5
作者：
Arnold AP
通讯作者：
Arnold AP
DOI：
10.3233/jad-180141
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Beam CR;Kaneshiro C;Jang JY;Reynolds CA;Pedersen NL;Gatz M
通讯作者：
Gatz M
影响因子：
4.4
作者：
Bundy JL;Vied C;Nowakowski RS
通讯作者：
Nowakowski RS