Autoimmunity and Gastric Cancer.

Autoimmunity and Gastric Cancer.
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DOI:
10.3390/ijms19020377
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发表时间:
2018-01-26
影响因子:
5.6
通讯作者:
Villalta D
Villalta D
中科院分区:
生物学2区
文献类型:
--
作者:
Bizzaro N;Antico A;Villalta D

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自身免疫性疾病患者的免疫反应改变可能易患恶性肿瘤,许多研究报道了慢性自身免疫性胃炎与胃癌之间的联系。肠上皮化生伴胃基底黏膜发育不良和嗜铬细胞增生是晚期自身免疫性胃炎的典型特征,被认为是前驱病变。自身免疫性胃炎与两种类型的胃肿瘤的发展有关:肠型和I型类胃癌。在这里,我们回顾自身免疫性胃炎与胃癌的关系以及胃肿瘤中存在的其他自身免疫性特征。
Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms.
DOI: 10.1002/ijc.2910300404
发表时间: 1982-01-01
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