Corpus callosum size and diffusion tensor anisotropy in adolescents and adults with schizophrenia.
Corpus callosum size and diffusion tensor anisotropy in adolescents and adults with schizophrenia.
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DOI：
10.1016/j.pscychresns.2014.12.005
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发表时间：
2015-03-30
影响因子：
11.3
通讯作者：
Hazlett EA
中科院分区：
文献类型：
--
作者：
Balevich EC;Haznedar MM;Wang E;Newmark RE;Bloom R;Schneiderman JS;Aronowitz J;Tang CY;Chu KW;Byne W;Buchsbaum MS;Hazlett EA
胼胝体已被认为是精神分裂症中功能失调的一个区域，但年龄与胼胝体病理之间的关系尚不清楚。对患有精神分裂症的成人（n=34）和青少年（n=17）以及年龄和性别匹配的成人（n=33）和青少年（n=15）进行磁共振成像（MRI）和弥散张量成像（DTI）检查。在每个参与者的MRI上手动追踪胼胝体，并将DTI扫描共同登记到MRI上。胼胝体分为5个前后节段。计算每段的面积和各向异性。两组患者均表现胼胝体各向异性降低；然而，青少年主要表现出前部区域的减少，而成人的后部区域的减少更为突出。与成年患者相比，青少年患者的绝对面积下降幅度更大，尤其是在前节段。然而，当考虑相对于整个脑白质体积的面积时，成年人显示出更大的减少。我们的研究结果表明，该疾病的初始阶段以额叶连接缺陷为特征，慢性期以后胼胝体缺陷为特征；或者，青少年发作的精神分裂症可能代表一种不同的或更严重的疾病形式。
The corpus callosum has been implicated as a region of dysfunctional connectivity in schizophrenia, but the association between age and callosal pathology is unclear. Magnetic resonance imaging (MRI) and diffusion-tensor imaging (DTI) were performed on adults (n=34) and adolescents (n=17) with schizophrenia and adult (n=33) and adolescent (n=15) age- and sex-matched healthy controls. The corpus callosum was manually traced on each participant’s MRI, and the DTI scan was co-registered to the MRI. The corpus callosum was divided into five anteroposterior segments. Area and anisotropy were calculated for each segment. Both patient groups demonstrated reduced callosal anisotropy; however, the adolescents exhibited reductions mostly in anterior regions while the reductions were more prominent in posterior regions of the adults. The adolescent patients showed greater decreases in absolute area as compared with the adult patients, particularly in the anterior segments. However, the adults showed greater reductions when area was considered relative to whole brain white matter volume. Our results suggest that the initial stages of the illness are characterized by deficiencies in frontal connections, and the chronic phase is characterized by deficits in the posterior corpus callosum; or, alternatively, adolescent-onset schizophrenia may represent a different or more severe form of the illness.
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影响因子：
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