Long-term changes in cognitive bias and coping response as a result of chronic unpredictable stress during adolescence.
Long-term changes in cognitive bias and coping response as a result of chronic unpredictable stress during adolescence.
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DOI：
10.3389/fnhum.2013.00328
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发表时间：
2013
影响因子：
2.9
通讯作者：
Braithwaite VA
中科院分区：
文献类型：
--
作者：
Chaby LE;Cavigelli SA;White A;Wang K;Braithwaite VA
在生命早期经历不良事件的动物通常会对其生理和行为产生终生的改变。早期生活压力的长期影响已经得到了广泛的研究，但很少有人关注青少年时期负面经历的后果。青春期是生命中特别敏感的时期，此时糖皮质激素“压力”激素反应的调节成熟，大脑中的特定区域发生相当大的变化。因此，在此期间的厌恶经历可能会对成人表型产生长期影响。在此，我们研究了青春期长期暴露于不可预测的慢性压力对成年大鼠决策、应对反应、认知偏差和探索行为的长期影响。将暴露于慢性不可预测压力（如隔离、拥挤、笼子倾斜）的大鼠与在整个发育过程中保持在标准、可预测条件下的对照动物进行比较。青春期不可预测的压力导致了一系列长期的行为和认知变化，包括负性认知偏差[F(1,12) = 5.000, P < 0.05]、应对反应改变[T(1,14) = 2.216, P = 0.04]和决策加速[T(1,14) = 3.245, P = 0.01]。在青春期长期承受压力也会导致大胆行为的短期增加；在最后一个应激源后15天的新对象测试中，暴露于慢性不可预测应激的动物离开熟悉的庇护所并接近新物体的潜伏期降低[T(1,14) = 2.240, P = 0.04；T(1,14) = 2.419, P = 0.03]。结果表明，青春期压力对行为和认知产生长期影响，影响动物对模糊刺激的解释、对不良事件的行为反应以及如何做出决策。
Animals that experience adverse events in early life often have life-long changes to their physiology and behavior. Long-term effects of stress during early life have been studied extensively, but less attention has been given to the consequences of negative experiences solely during the adolescent phase. Adolescence is a particularly sensitive period of life when regulation of the glucocorticoid “stress” hormone response matures and specific regions in the brain undergo considerable change. Aversive experiences during this time might, therefore, be expected to generate long-term consequences for the adult phenotype. Here we investigated the long-term effects of exposure to chronic unpredictable stress during adolescence on adult decision-making, coping response, cognitive bias, and exploratory behavior in rats. Rats exposed to chronic unpredictable stress (e.g., isolation, crowding, cage tilt) were compared to control animals that were maintained in standard, predictable conditions throughout development. Unpredictable stress during adolescence resulted in a suite of long-term behavioral and cognitive changes including a negative cognitive bias [F(1, 12) = 5.000, P < 0.05], altered coping response [T(1, 14) = 2.216, P = 0.04], and accelerated decision-making [T(1, 14) = 3.245, P = 0.01]. Exposure to chronic stress during adolescence also caused a short-term increase in boldness behaviors; in a novel object test 15 days after the last stressor, animals exposed to chronic unpredictable stress had decreased latencies to leave a familiar shelter and approach a novel object [T(1, 14) = 2.240, P = 0.04; T(1, 14) = 2.419, P = 0.03, respectively]. The results showed that stress during adolescence has long-term impacts on behavior and cognition that affect the interpretation of ambiguous stimuli, behavioral response to adverse events, and how animals make decisions.
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影响因子：
2.9
作者：
Cavigelli SA;Ragan CM;Michael KC;Kovacsics CE;Bruscke AP
通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
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通讯作者：
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影响因子：
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